|
CYP1A1 (Ile462Val)
|
Ile/Ile
|
4 (13.3)
|
32 (28.3)
|
.241*
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
Ile/Val
|
17 (56.7)
|
54 (47.8)
| |
2.52 (0.78-8.15); p = 0.123
|
2.52 (0.78-8.14); p = 0.124
|
5.08 (1.19-21.6); p = 0.028
|
|
Val/val
|
9 (30.0)
|
27 (23.9)
| |
2.67 (0.74-9.63); P = 0.134
|
2.66 (0.73-9.67); p = 0.138
|
3.31 (0.69-15.9); p = 0.135
|
|
Ile/val + Val/val
|
26 (86.7)
|
81 (71.7)
|
.104**
|
2.57 (0.83-7.95); P = 0.102
|
2.56 (0.83-7.95); p = 0.103
|
4.35 (1.08-17.5); p = 0.038
|
|
Val allele
|
35 (58.3)
|
108 (47.8)
| | | | |
|
CYP1B1 (Leu432Val)
|
Leu/Leu
|
26 (83.9)
|
79 (71.2)
|
.159
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
Leu/val
|
4 (12.9)
|
31 (27.9)
| |
0.39 (0.13-1.21); p = 0.105
|
0.39 (0.13-1.22); p = 0.105
|
0.39 (0.094-1.45); p = 0.174
|
|
Val/val
|
1 (3.2)
|
1 (0.9)
| |
3.04 (0.18-50.3); p = 0.438
|
3.03 (0.18-50.1); p = 0.439
|
-
|
|
Leu/val + Val/val
|
5 (16.1)
|
32 (28.8)
|
.174
|
0.48 (0.17-1.35); p = 0.161
|
0.47 (0.17-1.34); p = 0.160
|
0.39 (0.094-1.45); p = 0.174
|
|
Val allele
|
6 (9.7)
|
33 (14.9)
| | | | |
|
COMT (Val158Met)
|
Val/val
|
7 (22.6)
|
19 (16.8)
|
.504
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
Val/Met
|
11 (35.5)
|
53 (46.9)
| |
0.56 (0.19-1.66); p = 0.299
|
0.56 (0.19-1.67); p = 0.300
|
0.65 (0.19-2.16); p = 0.476
|
|
Met/met
|
13 (41.9)
|
41 (36.3)
| |
0.86 (0.29-2.53); p = 0.783
|
0.87 (0.29-2.56); P = 0.871
|
0.65 (0.19-2.26); p = 0.498
|
|
Val/Met-Met/Met
|
24 (77.4)
|
94 (83.2)
|
.441
|
0.69 (0.26-1.84); p = 0.461
|
0.69 (0.26-1.85); P = 0.463
|
0.65 (0.22-1.93); p = 0.435
|
|
Met allele
|
37 (59.7)
|
135 (59.7)
| | | | |
|
CYP17 (−34 T > C)
|
TT (A1/A1)
|
12 (40)
|
24 (21.2)
|
.107
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
TC (A1/A2)
|
12 (40)
|
57 (50.4)
| |
0.41 (0.16-1.05); p = 0.062
|
0.40 (0.16-1.03); p = 0.057
|
0.35 (0.12-1.05); p = 0.06
|
|
CC (A2/A2)
|
6 (20)
|
32 (28.3)
| |
0.36 (0.12-1.10); p = 0.073
|
0.35 (0.11-1.03); p = 0.067
|
0.25 (0.063-0.95); P = 0.042
|
|
A1/A2 + A2/A2
|
18 (60)
|
89 (78.8)
|
.054
|
0.39 (0.16-0.93); p = 0.033
|
0.38 (0.16-1.04); p = 0.030
|
0.34 (0.12-0.94); P = 0.038
|
|
A2 allele
|
24 (40)
|
121 (53.5)
| | | | |
|
CYP19 (C > T)
|
CC
|
23 (74.2)
|
79 (69.3)
|
.424
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
CT
|
8 (25.8)
|
29 (25.4)
| |
0.95 (0.38-2.36); p = 0.908
|
0.94 (0.38-2.35) p = 0.944
|
1.29 (0.45-3.71); p = 0.639
|
|
TT
|
0 (0)
|
6 (5.3)
| |
-
|
-
|
-
|
|
CT + TT
|
8 (25.8)
|
35 (30.7)
|
.662
|
0.79 (0.32-1.95); p = 0.608
|
0.78 (0.32-1.93); P = 0.594
|
1.13 (0.39-3.23); p = 0.821
|
|
T allele
|
8 (12.9)
|
41 (18)
| | | | |
|
CYP19 (TTTA)n
|
F (7–10)
|
27 (87.1)
|
76 (75.2)
|
.317
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
SF
|
4 (12.9)
|
22 (21.8)
| |
0.51 (0.16-1.62); p = 0.255
|
0.50 (0.16-1.58); p = 0.236
|
0.70 (0.2-2.45); p = 0.577
|
|
S (11–13)
|
0 (0)
|
3 (3.0)
| |
-
|
-
|
-
|
|
SF + S
|
4 (12.9)
|
25 (24.8)
|
.217
|
0.45 (0.14-1.41); p = 0.17
|
0.44 (0.14-1.39); p = 0.160
|
0.70 (0.20-2.45); p = 0.577
|
|
S allele
|
4 (6.5)
|
28 (13.9)
| | | | |
|
BRCA1 (Cys39Gly)
|
Cys/Cys
|
28 (90.3)
|
106 (97.2)
|
.122
|
1.00 (Ref.)
|
1.00 (Ref.)
|
1.00 (Ref.)
|
|
Cys/Gly
|
3 (9.7)
|
3 (2.8)
| |
3.79 (0.73-19.7); p = 0.115
|
4.29 (0.77-23.9); p = 0.097
|
5.14(0.45-58.9); p = 0.189
|
|
Gly /Gly
|
0 (0)
|
0 (0)
| | | | |
|
Gly allele
|
3 (4.8)
|
3 (1.4)
| | | | |
