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Table 2 Distribution of genotypes and the relationship between polymorphisms of studied genes and the risk of female breast cancer in Inuit
| Gene | Genotype | Case N (%) | Control N (%) | P (χ2) | Odds ratio (95% CI); p-value | ||
|---|---|---|---|---|---|---|---|
| Crude | Age adjusted | Age and cotinine adjusted | |||||
| CYP1A1 (Ile462Val) | Ile/Ile | 4 (13.3) | 32 (28.3) | .241* | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Ile/Val | 17 (56.7) | 54 (47.8) | 2.52 (0.78-8.15); p = 0.123 | 2.52 (0.78-8.14); p = 0.124 | 5.08 (1.19-21.6); p = 0.028 | ||
| Val/val | 9 (30.0) | 27 (23.9) | 2.67 (0.74-9.63); P = 0.134 | 2.66 (0.73-9.67); p = 0.138 | 3.31 (0.69-15.9); p = 0.135 | ||
| Ile/val + Val/val | 26 (86.7) | 81 (71.7) | .104** | 2.57 (0.83-7.95); P = 0.102 | 2.56 (0.83-7.95); p = 0.103 | 4.35 (1.08-17.5); p = 0.038 | |
| Val allele | 35 (58.3) | 108 (47.8) | |||||
| CYP1B1 (Leu432Val) | Leu/Leu | 26 (83.9) | 79 (71.2) | .159 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Leu/val | 4 (12.9) | 31 (27.9) | 0.39 (0.13-1.21); p = 0.105 | 0.39 (0.13-1.22); p = 0.105 | 0.39 (0.094-1.45); p = 0.174 | ||
| Val/val | 1 (3.2) | 1 (0.9) | 3.04 (0.18-50.3); p = 0.438 | 3.03 (0.18-50.1); p = 0.439 | - | ||
| Leu/val + Val/val | 5 (16.1) | 32 (28.8) | .174 | 0.48 (0.17-1.35); p = 0.161 | 0.47 (0.17-1.34); p = 0.160 | 0.39 (0.094-1.45); p = 0.174 | |
| Val allele | 6 (9.7) | 33 (14.9) | |||||
| COMT (Val158Met) | Val/val | 7 (22.6) | 19 (16.8) | .504 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Val/Met | 11 (35.5) | 53 (46.9) | 0.56 (0.19-1.66); p = 0.299 | 0.56 (0.19-1.67); p = 0.300 | 0.65 (0.19-2.16); p = 0.476 | ||
| Met/met | 13 (41.9) | 41 (36.3) | 0.86 (0.29-2.53); p = 0.783 | 0.87 (0.29-2.56); P = 0.871 | 0.65 (0.19-2.26); p = 0.498 | ||
| Val/Met-Met/Met | 24 (77.4) | 94 (83.2) | .441 | 0.69 (0.26-1.84); p = 0.461 | 0.69 (0.26-1.85); P = 0.463 | 0.65 (0.22-1.93); p = 0.435 | |
| Met allele | 37 (59.7) | 135 (59.7) | |||||
| CYP17 (−34 T > C) | TT (A1/A1) | 12 (40) | 24 (21.2) | .107 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| TC (A1/A2) | 12 (40) | 57 (50.4) | 0.41 (0.16-1.05); p = 0.062 | 0.40 (0.16-1.03); p = 0.057 | 0.35 (0.12-1.05); p = 0.06 | ||
| CC (A2/A2) | 6 (20) | 32 (28.3) | 0.36 (0.12-1.10); p = 0.073 | 0.35 (0.11-1.03); p = 0.067 | 0.25 (0.063-0.95); P = 0.042 | ||
| A1/A2 + A2/A2 | 18 (60) | 89 (78.8) | .054 | 0.39 (0.16-0.93); p = 0.033 | 0.38 (0.16-1.04); p = 0.030 | 0.34 (0.12-0.94); P = 0.038 | |
| A2 allele | 24 (40) | 121 (53.5) | |||||
| CYP19 (C > T) | CC | 23 (74.2) | 79 (69.3) | .424 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| CT | 8 (25.8) | 29 (25.4) | 0.95 (0.38-2.36); p = 0.908 | 0.94 (0.38-2.35) p = 0.944 | 1.29 (0.45-3.71); p = 0.639 | ||
| TT | 0 (0) | 6 (5.3) | - | - | - | ||
| CT + TT | 8 (25.8) | 35 (30.7) | .662 | 0.79 (0.32-1.95); p = 0.608 | 0.78 (0.32-1.93); P = 0.594 | 1.13 (0.39-3.23); p = 0.821 | |
| T allele | 8 (12.9) | 41 (18) | |||||
| CYP19 (TTTA)n | F (7–10) | 27 (87.1) | 76 (75.2) | .317 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| SF | 4 (12.9) | 22 (21.8) | 0.51 (0.16-1.62); p = 0.255 | 0.50 (0.16-1.58); p = 0.236 | 0.70 (0.2-2.45); p = 0.577 | ||
| S (11–13) | 0 (0) | 3 (3.0) | - | - | - | ||
| SF + S | 4 (12.9) | 25 (24.8) | .217 | 0.45 (0.14-1.41); p = 0.17 | 0.44 (0.14-1.39); p = 0.160 | 0.70 (0.20-2.45); p = 0.577 | |
| S allele | 4 (6.5) | 28 (13.9) | |||||
| BRCA1 (Cys39Gly) | Cys/Cys | 28 (90.3) | 106 (97.2) | .122 | 1.00 (Ref.) | 1.00 (Ref.) | 1.00 (Ref.) |
| Cys/Gly | 3 (9.7) | 3 (2.8) | 3.79 (0.73-19.7); p = 0.115 | 4.29 (0.77-23.9); p = 0.097 | 5.14(0.45-58.9); p = 0.189 | ||
| Gly /Gly | 0 (0) | 0 (0) | |||||
| Gly allele | 3 (4.8) | 3 (1.4) | |||||
