Skip to main content

Table 2 Distribution of genotypes and the relationship between polymorphisms of studied genes and the risk of female breast cancer in Inuit

From: Polymorphisms in Phase I and Phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case–control study in Inuit women

Gene

Genotype

Case N (%)

Control N (%)

P (χ2)

Odds ratio (95% CI); p-value

Crude

Age adjusted

Age and cotinine adjusted

CYP1A1 (Ile462Val)

Ile/Ile

4 (13.3)

32 (28.3)

.241*

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

Ile/Val

17 (56.7)

54 (47.8)

 

2.52 (0.78-8.15); p = 0.123

2.52 (0.78-8.14); p = 0.124

5.08 (1.19-21.6); p = 0.028

Val/val

9 (30.0)

27 (23.9)

 

2.67 (0.74-9.63); P = 0.134

2.66 (0.73-9.67); p = 0.138

3.31 (0.69-15.9); p = 0.135

Ile/val + Val/val

26 (86.7)

81 (71.7)

.104**

2.57 (0.83-7.95); P = 0.102

2.56 (0.83-7.95); p = 0.103

4.35 (1.08-17.5); p = 0.038

Val allele

35 (58.3)

108 (47.8)

    

CYP1B1 (Leu432Val)

Leu/Leu

26 (83.9)

79 (71.2)

.159

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

Leu/val

4 (12.9)

31 (27.9)

 

0.39 (0.13-1.21); p = 0.105

0.39 (0.13-1.22); p = 0.105

0.39 (0.094-1.45); p = 0.174

Val/val

1 (3.2)

1 (0.9)

 

3.04 (0.18-50.3); p = 0.438

3.03 (0.18-50.1); p = 0.439

-

Leu/val + Val/val

5 (16.1)

32 (28.8)

.174

0.48 (0.17-1.35); p = 0.161

0.47 (0.17-1.34); p = 0.160

0.39 (0.094-1.45); p = 0.174

Val allele

6 (9.7)

33 (14.9)

    

COMT (Val158Met)

Val/val

7 (22.6)

19 (16.8)

.504

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

Val/Met

11 (35.5)

53 (46.9)

 

0.56 (0.19-1.66); p = 0.299

0.56 (0.19-1.67); p = 0.300

0.65 (0.19-2.16); p = 0.476

Met/met

13 (41.9)

41 (36.3)

 

0.86 (0.29-2.53); p = 0.783

0.87 (0.29-2.56); P = 0.871

0.65 (0.19-2.26); p = 0.498

Val/Met-Met/Met

24 (77.4)

94 (83.2)

.441

0.69 (0.26-1.84); p = 0.461

0.69 (0.26-1.85); P = 0.463

0.65 (0.22-1.93); p = 0.435

Met allele

37 (59.7)

135 (59.7)

    

CYP17 (−34 T > C)

TT (A1/A1)

12 (40)

24 (21.2)

.107

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

TC (A1/A2)

12 (40)

57 (50.4)

 

0.41 (0.16-1.05); p = 0.062

0.40 (0.16-1.03); p = 0.057

0.35 (0.12-1.05); p = 0.06

CC (A2/A2)

6 (20)

32 (28.3)

 

0.36 (0.12-1.10); p = 0.073

0.35 (0.11-1.03); p = 0.067

0.25 (0.063-0.95); P = 0.042

A1/A2 + A2/A2

18 (60)

89 (78.8)

.054

0.39 (0.16-0.93); p = 0.033

0.38 (0.16-1.04); p = 0.030

0.34 (0.12-0.94); P = 0.038

A2 allele

24 (40)

121 (53.5)

    

CYP19 (C > T)

CC

23 (74.2)

79 (69.3)

.424

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

CT

8 (25.8)

29 (25.4)

 

0.95 (0.38-2.36); p = 0.908

0.94 (0.38-2.35) p = 0.944

1.29 (0.45-3.71); p = 0.639

TT

0 (0)

6 (5.3)

 

-

-

-

CT + TT

8 (25.8)

35 (30.7)

.662

0.79 (0.32-1.95); p = 0.608

0.78 (0.32-1.93); P = 0.594

1.13 (0.39-3.23); p = 0.821

T allele

8 (12.9)

41 (18)

    

CYP19 (TTTA)n

F (7–10)

27 (87.1)

76 (75.2)

.317

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

SF

4 (12.9)

22 (21.8)

 

0.51 (0.16-1.62); p = 0.255

0.50 (0.16-1.58); p = 0.236

0.70 (0.2-2.45); p = 0.577

S (11–13)

0 (0)

3 (3.0)

 

-

-

-

SF + S

4 (12.9)

25 (24.8)

.217

0.45 (0.14-1.41); p = 0.17

0.44 (0.14-1.39); p = 0.160

0.70 (0.20-2.45); p = 0.577

S allele

4 (6.5)

28 (13.9)

    

BRCA1 (Cys39Gly)

Cys/Cys

28 (90.3)

106 (97.2)

.122

1.00 (Ref.)

1.00 (Ref.)

1.00 (Ref.)

Cys/Gly

3 (9.7)

3 (2.8)

 

3.79 (0.73-19.7); p = 0.115

4.29 (0.77-23.9); p = 0.097

5.14(0.45-58.9); p = 0.189

Gly /Gly

0 (0)

0 (0)

    

Gly allele

3 (4.8)

3 (1.4)

    
  1. *p-value for comparison between the 3 genotypes (wt/wt; wt/var; var/var) using chi-2 analysis.
  2. **p-value for comparison between the wt/wt and wt/var+var/var (dominant model).
  3. Boldface indicate significance at p<0.05.
Back to article page

Environmental Health

ISSN: 1476-069X