Skip to main content

Advertisement

Table 4 Odds ratios of breast cancer and 95% confidence intervals associated with PFOS and PFOA among breast cancer patients and controls

From: Polymorphisms in Phase I and Phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case–control study in Inuit women

Variables N (Ca/Co) Crude p N (Ca/Co) Age adjusted p N (Ca/Co) Age + cotinine adjusted p
OR 95% CI OR 95% CI OR 95% CI
CYP1A1 PFOS             
Ile/Ile Low 1/17 1 (Ref)    1/17 1 (Ref)    0/17 1 (Ref)   
Ile/Ile high 3/11 4.64 0.43-50.4 .208 3/11 6.33 0.35-114.1 .211 3/11    
Ile/Val + Val/Val Low 2/32 1 (Ref)    2/32 1 (Ref)    2/32 1 (Ref)   
Ile/Val + Val/Val High 24/36 10.67 2.34-48.7 .002 24/36 12.4 2.57-59.9 .002 20/36 12.1 1.29-115 .029
CYP1B1              
Leu/Leu Low 3/28 1 (Ref)    3/28 1 (Ref)    2/28 1 (Ref)   
Leu/Leu High 23/38 5.6 1.5-20.7 .009 23/38 7.3 1.80-29.4 .005 20/38 11.2 1.8-71.1 .011
Leu/val + Val/Val Low 0/20 1 (Ref)    0/20 1 (Ref)    0/20 1 (Ref)   
Leu/val + Val/Val High 5/8 0 (12.5)    5/8     4/8    
COMT              
Val/Val Low 1/9 1 (Ref)    1/9 1 (Ref)    0/9 1 (Ref)   
Val/Val High 6/8 6.75 0.66-68.8 .107 6/8 7.13 0.65-77.6 .107 5/8    
Val/Met + Met/Met Low 2/40 1 (Ref)    2/40 1 (Ref)    2/40 1 (Ref)   
Val/Met + Met/Met High 22/39 11.28 2.48-51.2 .002 22/39 15.36 3.02-78.2 .001 19/39 16.8 1.68-167 .016
CYP17              
A1/A1 Low 0/12     0/12     0/12    
A1/A1 High 10/12     10/12     10/9    
A1/A2 + A2/A2 Low 3/37 1 (Ref)    3/37 1 (Ref)    2/37 1 (Ref)   
A1/A2 + A2/A2 High 15/37 5.00 1.34-18.7 .017 15/37 5.67 1.38-23.4 .016 13/36 18.2 1.67-198.8 .017
CYP19_CT              
CC Low 3/34 1 (Ref)    3/34 1 (Ref)    1/33 1 (Ref)   
CC High 20/29 7.86 2.11-29.2 .002 20/29 8.85 2.15-36.4 .003 14/27 9.6 1.48-62.4 .018
CT + TT Low 0/15     0/15     0/15    
CT + TT High 8/19     8/19     8/19    
CYP19_TTTA              
(TTTA)8–10 Low 3/35 1 (Ref)    3/35 1 (Ref)    2/35 1 (Ref)   
(TTTA)8–10 High 24/29 9.66 2.64-35.3 .001 24/29 8.92 2.33-34.2 .001 20/29 29.3 2.89-298 .004
(TTTA)11–13 Low 0/11     0/11     0/11    
(TTTA)11–13 High 4/13     4/13     4/12    
Ile/Ile Low 1/15 1 (Ref)    1/15 1 (Ref)    1/15 1 (Ref)   
Ile/Ile High 3/13 3.46 0.32-37.5 .307 3/13 4.26 0.24-75.3 .322 3/13 10.5 0.12-907 .303
Ile/Val + Val/Val Low 6/33 1 (Ref)    6/33 1 (Ref)    5/33 1 (Ref)   
Ile/Val + Val/Val High 20/35 3.14 1.12-8.79 .029 20/35 3.30 1.13-9.7 .030 17/35 3.58 0.81-15.8 .092
CYP1B1              
Leu/Leu Low 8/27 1 (Ref)    8/27 1 (Ref)    6/27 1 (Ref)   
Leu/Leu High 18/39 1.6 0.59-4.10 .369 18/39 1.6 0.56-4.70 .351 16/39 2.1 0.59-7.6 .25
Leu/val + Val/Val Low 0/20 1 (Ref)        0/20    
Leu/val + Val/Val High 5/8 0 (12.5)        4/8    
COMT              
Val/Val Low 3/8 1 (Ref)    3/8 1 (Ref)    2/8 1 (Ref)   
Val/Val High 4/9 1.19 0.20-6.99 .851 4/9 1.15 0.19-6.87 .882 3/9 8.32 0.29-235 .215
Val/Met + Met/Met Low 5/40 1 (Ref)    5/40 1 (Ref)    4/40 1 (Ref)   
Val/Met + Met/Met High 19/39 3.89 1.32-11.5 .014 19/39 4.68 1.42-15.5 .011 17/39 3.73 0.86-16.3 .080
CYP17              
A1/A1 Low 3/10 1 (Ref)    3/10 1 (Ref)    2/10 1 (Ref)   
A1/A1 High 9/12 2.50 0.53-11.8 .247 9/12 2.35 0.45-12.2 .309 8/12 0.84 0.093-0.60 .877
A1/A2 + A2/A2 Low 4/38 1 (Ref)    4/38 1 (Ref)    3/38 1 (Ref)   
A1/A2 + A2/A2 High 14/36 3.69 1.11-12.3 .033 14/36 4.00 1.10-14.5 .035 12/36 8.79 1.22-63.5 .031
CYP19_CT              
CC Low 7/32 1 (Ref)    7/32 1 (Ref)    5/32 1 (Ref)   
CC High 16/31 2.36 0.85-6.55 .099 16/31 2.21 0.705-6.95 .173 13/31 2.44 0.57-10.4 .227
CT + TT Low 1/16 1 (Ref)    1/16 1 (Ref)    1/16 1 (Ref)   
CT + TT High 7/18 6.22 0.69-56.2 .104 7/18 7.18 .737-67.0 .090 7/18 4.99 0.34-74.7 .244
CYP19_TTTA              
(TTTA)8–10 Low 8/33 1 (Ref)    8/33 1 (Ref)    6/33 1 (Ref)   
(TTTA)8–10 High 19/31 2.53 0.97-6.61 .058 19/31 2.07 .753-5.71 .158 16/31 3.28 0.74-14.6 .119
(TTTA)11–13 Low 0/12 1 (Ref)    0/12 1 (Ref)    0/12 1 (Ref)   
(TTTA)11–13 High 4/12 0    4/12     4/12    
  1. Ca: case, co: control.