Skip to main content

Table 4 Odds ratios of breast cancer and 95% confidence intervals associated with PFOS and PFOA among breast cancer patients and controls

From: Polymorphisms in Phase I and Phase II genes and breast cancer risk and relations to persistent organic pollutant exposure: a case–control study in Inuit women

Variables

N (Ca/Co)

Crude

p

N (Ca/Co)

Age adjusted

p

N (Ca/Co)

Age + cotinine adjusted

p

OR

95% CI

OR

95% CI

OR

95% CI

CYP1A1

PFOS

            

Ile/Ile

Low

1/17

1 (Ref)

  

1/17

1 (Ref)

  

0/17

1 (Ref)

  

Ile/Ile

high

3/11

4.64

0.43-50.4

.208

3/11

6.33

0.35-114.1

.211

3/11

   

Ile/Val + Val/Val

Low

2/32

1 (Ref)

  

2/32

1 (Ref)

  

2/32

1 (Ref)

  

Ile/Val + Val/Val

High

24/36

10.67

2.34-48.7

.002

24/36

12.4

2.57-59.9

.002

20/36

12.1

1.29-115

.029

CYP1B1

             

Leu/Leu

Low

3/28

1 (Ref)

  

3/28

1 (Ref)

  

2/28

1 (Ref)

  

Leu/Leu

High

23/38

5.6

1.5-20.7

.009

23/38

7.3

1.80-29.4

.005

20/38

11.2

1.8-71.1

.011

Leu/val + Val/Val

Low

0/20

1 (Ref)

  

0/20

1 (Ref)

  

0/20

1 (Ref)

  

Leu/val + Val/Val

High

5/8

0 (12.5)

  

5/8

   

4/8

   

COMT

             

Val/Val

Low

1/9

1 (Ref)

  

1/9

1 (Ref)

  

0/9

1 (Ref)

  

Val/Val

High

6/8

6.75

0.66-68.8

.107

6/8

7.13

0.65-77.6

.107

5/8

   

Val/Met + Met/Met

Low

2/40

1 (Ref)

  

2/40

1 (Ref)

  

2/40

1 (Ref)

  

Val/Met + Met/Met

High

22/39

11.28

2.48-51.2

.002

22/39

15.36

3.02-78.2

.001

19/39

16.8

1.68-167

.016

CYP17

             

A1/A1

Low

0/12

   

0/12

   

0/12

   

A1/A1

High

10/12

   

10/12

   

10/9

   

A1/A2 + A2/A2

Low

3/37

1 (Ref)

  

3/37

1 (Ref)

  

2/37

1 (Ref)

  

A1/A2 + A2/A2

High

15/37

5.00

1.34-18.7

.017

15/37

5.67

1.38-23.4

.016

13/36

18.2

1.67-198.8

.017

CYP19_CT

             

CC

Low

3/34

1 (Ref)

  

3/34

1 (Ref)

  

1/33

1 (Ref)

  

CC

High

20/29

7.86

2.11-29.2

.002

20/29

8.85

2.15-36.4

.003

14/27

9.6

1.48-62.4

.018

CT + TT

Low

0/15

   

0/15

   

0/15

   

CT + TT

High

8/19

   

8/19

   

8/19

   

CYP19_TTTA

             

(TTTA)8–10

Low

3/35

1 (Ref)

  

3/35

1 (Ref)

  

2/35

1 (Ref)

  

(TTTA)8–10

High

24/29

9.66

2.64-35.3

.001

24/29

8.92

2.33-34.2

.001

20/29

29.3

2.89-298

.004

(TTTA)11–13

Low

0/11

   

0/11

   

0/11

   

(TTTA)11–13

High

4/13

   

4/13

   

4/12

   

Ile/Ile

Low

1/15

1 (Ref)

  

1/15

1 (Ref)

  

1/15

1 (Ref)

  

Ile/Ile

High

3/13

3.46

0.32-37.5

.307

3/13

4.26

0.24-75.3

.322

3/13

10.5

0.12-907

.303

Ile/Val + Val/Val

Low

6/33

1 (Ref)

  

6/33

1 (Ref)

  

5/33

1 (Ref)

  

Ile/Val + Val/Val

High

20/35

3.14

1.12-8.79

.029

20/35

3.30

1.13-9.7

.030

17/35

3.58

0.81-15.8

.092

CYP1B1

             

Leu/Leu

Low

8/27

1 (Ref)

  

8/27

1 (Ref)

  

6/27

1 (Ref)

  

Leu/Leu

High

18/39

1.6

0.59-4.10

.369

18/39

1.6

0.56-4.70

.351

16/39

2.1

0.59-7.6

.25

Leu/val + Val/Val

Low

0/20

1 (Ref)

      

0/20

   

Leu/val + Val/Val

High

5/8

0 (12.5)

      

4/8

   

COMT

             

Val/Val

Low

3/8

1 (Ref)

  

3/8

1 (Ref)

  

2/8

1 (Ref)

  

Val/Val

High

4/9

1.19

0.20-6.99

.851

4/9

1.15

0.19-6.87

.882

3/9

8.32

0.29-235

.215

Val/Met + Met/Met

Low

5/40

1 (Ref)

  

5/40

1 (Ref)

  

4/40

1 (Ref)

  

Val/Met + Met/Met

High

19/39

3.89

1.32-11.5

.014

19/39

4.68

1.42-15.5

.011

17/39

3.73

0.86-16.3

.080

CYP17

             

A1/A1

Low

3/10

1 (Ref)

  

3/10

1 (Ref)

  

2/10

1 (Ref)

  

A1/A1

High

9/12

2.50

0.53-11.8

.247

9/12

2.35

0.45-12.2

.309

8/12

0.84

0.093-0.60

.877

A1/A2 + A2/A2

Low

4/38

1 (Ref)

  

4/38

1 (Ref)

  

3/38

1 (Ref)

  

A1/A2 + A2/A2

High

14/36

3.69

1.11-12.3

.033

14/36

4.00

1.10-14.5

.035

12/36

8.79

1.22-63.5

.031

CYP19_CT

             

CC

Low

7/32

1 (Ref)

  

7/32

1 (Ref)

  

5/32

1 (Ref)

  

CC

High

16/31

2.36

0.85-6.55

.099

16/31

2.21

0.705-6.95

.173

13/31

2.44

0.57-10.4

.227

CT + TT

Low

1/16

1 (Ref)

  

1/16

1 (Ref)

  

1/16

1 (Ref)

  

CT + TT

High

7/18

6.22

0.69-56.2

.104

7/18

7.18

.737-67.0

.090

7/18

4.99

0.34-74.7

.244

CYP19_TTTA

             

(TTTA)8–10

Low

8/33

1 (Ref)

  

8/33

1 (Ref)

  

6/33

1 (Ref)

  

(TTTA)8–10

High

19/31

2.53

0.97-6.61

.058

19/31

2.07

.753-5.71

.158

16/31

3.28

0.74-14.6

.119

(TTTA)11–13

Low

0/12

1 (Ref)

  

0/12

1 (Ref)

  

0/12

1 (Ref)

  

(TTTA)11–13

High

4/12

0

  

4/12

   

4/12

   
  1. Ca: case, co: control.