Variables | N (Ca/Co) | Crude | p | N (Ca/Co) | Age adjusted | p | N (Ca/Co) | Age + cotinine adjusted | p | ||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
OR | 95% CI | OR | 95% CI | OR | 95% CI | ||||||||
CYP1A1 | PFOS | ||||||||||||
Ile/Ile | Low | 1/17 | 1 (Ref) | 1/17 | 1 (Ref) | 0/17 | 1 (Ref) | ||||||
Ile/Ile | high | 3/11 | 4.64 | 0.43-50.4 | .208 | 3/11 | 6.33 | 0.35-114.1 | .211 | 3/11 | |||
Ile/Val + Val/Val | Low | 2/32 | 1 (Ref) | 2/32 | 1 (Ref) | 2/32 | 1 (Ref) | ||||||
Ile/Val + Val/Val | High | 24/36 | 10.67 | 2.34-48.7 | .002 | 24/36 | 12.4 | 2.57-59.9 | .002 | 20/36 | 12.1 | 1.29-115 | .029 |
CYP1B1 | |||||||||||||
Leu/Leu | Low | 3/28 | 1 (Ref) | 3/28 | 1 (Ref) | 2/28 | 1 (Ref) | ||||||
Leu/Leu | High | 23/38 | 5.6 | 1.5-20.7 | .009 | 23/38 | 7.3 | 1.80-29.4 | .005 | 20/38 | 11.2 | 1.8-71.1 | .011 |
Leu/val + Val/Val | Low | 0/20 | 1 (Ref) | 0/20 | 1 (Ref) | 0/20 | 1 (Ref) | ||||||
Leu/val + Val/Val | High | 5/8 | 0 (12.5) | 5/8 | 4/8 | ||||||||
COMT | |||||||||||||
Val/Val | Low | 1/9 | 1 (Ref) | 1/9 | 1 (Ref) | 0/9 | 1 (Ref) | ||||||
Val/Val | High | 6/8 | 6.75 | 0.66-68.8 | .107 | 6/8 | 7.13 | 0.65-77.6 | .107 | 5/8 | |||
Val/Met + Met/Met | Low | 2/40 | 1 (Ref) | 2/40 | 1 (Ref) | 2/40 | 1 (Ref) | ||||||
Val/Met + Met/Met | High | 22/39 | 11.28 | 2.48-51.2 | .002 | 22/39 | 15.36 | 3.02-78.2 | .001 | 19/39 | 16.8 | 1.68-167 | .016 |
CYP17 | |||||||||||||
A1/A1 | Low | 0/12 | 0/12 | 0/12 | |||||||||
A1/A1 | High | 10/12 | 10/12 | 10/9 | |||||||||
A1/A2 + A2/A2 | Low | 3/37 | 1 (Ref) | 3/37 | 1 (Ref) | 2/37 | 1 (Ref) | ||||||
A1/A2 + A2/A2 | High | 15/37 | 5.00 | 1.34-18.7 | .017 | 15/37 | 5.67 | 1.38-23.4 | .016 | 13/36 | 18.2 | 1.67-198.8 | .017 |
CYP19_CT | |||||||||||||
CC | Low | 3/34 | 1 (Ref) | 3/34 | 1 (Ref) | 1/33 | 1 (Ref) | ||||||
CC | High | 20/29 | 7.86 | 2.11-29.2 | .002 | 20/29 | 8.85 | 2.15-36.4 | .003 | 14/27 | 9.6 | 1.48-62.4 | .018 |
CT + TT | Low | 0/15 | 0/15 | 0/15 | |||||||||
CT + TT | High | 8/19 | 8/19 | 8/19 | |||||||||
CYP19_TTTA | |||||||||||||
(TTTA)8–10 | Low | 3/35 | 1 (Ref) | 3/35 | 1 (Ref) | 2/35 | 1 (Ref) | ||||||
(TTTA)8–10 | High | 24/29 | 9.66 | 2.64-35.3 | .001 | 24/29 | 8.92 | 2.33-34.2 | .001 | 20/29 | 29.3 | 2.89-298 | .004 |
(TTTA)11–13 | Low | 0/11 | 0/11 | 0/11 | |||||||||
(TTTA)11–13 | High | 4/13 | 4/13 | 4/12 | |||||||||
Ile/Ile | Low | 1/15 | 1 (Ref) | 1/15 | 1 (Ref) | 1/15 | 1 (Ref) | ||||||
Ile/Ile | High | 3/13 | 3.46 | 0.32-37.5 | .307 | 3/13 | 4.26 | 0.24-75.3 | .322 | 3/13 | 10.5 | 0.12-907 | .303 |
Ile/Val + Val/Val | Low | 6/33 | 1 (Ref) | 6/33 | 1 (Ref) | 5/33 | 1 (Ref) | ||||||
Ile/Val + Val/Val | High | 20/35 | 3.14 | 1.12-8.79 | .029 | 20/35 | 3.30 | 1.13-9.7 | .030 | 17/35 | 3.58 | 0.81-15.8 | .092 |
CYP1B1 | |||||||||||||
Leu/Leu | Low | 8/27 | 1 (Ref) | 8/27 | 1 (Ref) | 6/27 | 1 (Ref) | ||||||
Leu/Leu | High | 18/39 | 1.6 | 0.59-4.10 | .369 | 18/39 | 1.6 | 0.56-4.70 | .351 | 16/39 | 2.1 | 0.59-7.6 | .25 |
Leu/val + Val/Val | Low | 0/20 | 1 (Ref) | 0/20 | |||||||||
Leu/val + Val/Val | High | 5/8 | 0 (12.5) | 4/8 | |||||||||
COMT | |||||||||||||
Val/Val | Low | 3/8 | 1 (Ref) | 3/8 | 1 (Ref) | 2/8 | 1 (Ref) | ||||||
Val/Val | High | 4/9 | 1.19 | 0.20-6.99 | .851 | 4/9 | 1.15 | 0.19-6.87 | .882 | 3/9 | 8.32 | 0.29-235 | .215 |
Val/Met + Met/Met | Low | 5/40 | 1 (Ref) | 5/40 | 1 (Ref) | 4/40 | 1 (Ref) | ||||||
Val/Met + Met/Met | High | 19/39 | 3.89 | 1.32-11.5 | .014 | 19/39 | 4.68 | 1.42-15.5 | .011 | 17/39 | 3.73 | 0.86-16.3 | .080 |
CYP17 | |||||||||||||
A1/A1 | Low | 3/10 | 1 (Ref) | 3/10 | 1 (Ref) | 2/10 | 1 (Ref) | ||||||
A1/A1 | High | 9/12 | 2.50 | 0.53-11.8 | .247 | 9/12 | 2.35 | 0.45-12.2 | .309 | 8/12 | 0.84 | 0.093-0.60 | .877 |
A1/A2 + A2/A2 | Low | 4/38 | 1 (Ref) | 4/38 | 1 (Ref) | 3/38 | 1 (Ref) | ||||||
A1/A2 + A2/A2 | High | 14/36 | 3.69 | 1.11-12.3 | .033 | 14/36 | 4.00 | 1.10-14.5 | .035 | 12/36 | 8.79 | 1.22-63.5 | .031 |
CYP19_CT | |||||||||||||
CC | Low | 7/32 | 1 (Ref) | 7/32 | 1 (Ref) | 5/32 | 1 (Ref) | ||||||
CC | High | 16/31 | 2.36 | 0.85-6.55 | .099 | 16/31 | 2.21 | 0.705-6.95 | .173 | 13/31 | 2.44 | 0.57-10.4 | .227 |
CT + TT | Low | 1/16 | 1 (Ref) | 1/16 | 1 (Ref) | 1/16 | 1 (Ref) | ||||||
CT + TT | High | 7/18 | 6.22 | 0.69-56.2 | .104 | 7/18 | 7.18 | .737-67.0 | .090 | 7/18 | 4.99 | 0.34-74.7 | .244 |
CYP19_TTTA | |||||||||||||
(TTTA)8–10 | Low | 8/33 | 1 (Ref) | 8/33 | 1 (Ref) | 6/33 | 1 (Ref) | ||||||
(TTTA)8–10 | High | 19/31 | 2.53 | 0.97-6.61 | .058 | 19/31 | 2.07 | .753-5.71 | .158 | 16/31 | 3.28 | 0.74-14.6 | .119 |
(TTTA)11–13 | Low | 0/12 | 1 (Ref) | 0/12 | 1 (Ref) | 0/12 | 1 (Ref) | ||||||
(TTTA)11–13 | High | 4/12 | 0 | 4/12 | 4/12 |