Genetic variation in the CYP2B6 Gene is related to circulating 2,2’,4,4’-tetrabromodiphenyl ether (BDE-47) concentrations: an observational population-based study

Table 1 Association between SNPs in the CYP2B6 gene and circulating lipid-normalized levels of BDE-47

SNP^a	position	Minor allele/major allele	MAF^b	n_obsin the analysis	Beta (95% CI) on natural logaritm scale	P-value (Bonferroni-corrected p-value for significance = 0.0021)
rs1808682^c	41489448	A/G	0.23	920	0.11 (0.026, 0.19)	9.5*10^-3
rs3760657	41495433	G/A	0.12	924	0.16 (0.058, 0.27)	2.5*10^-3
rs2099361	41498348	C/A	0.36	923	-0.18 (-0.25, -0.11)	2.8*10^-7
rs2014141	41499989	A/G	0.41	924	-0.21 (-0.28, -0.14)	4.9*10^-9
rs8192711	41500057	A/G	0.05	923	-0.12 (-0.27, 0.031)	0.12
rs8100458	41500213	C/T	0.35	924	0.17 (0.10, 0.24)	3.4*10^-6
rs4803415	41500593	T/C	0.10	886	0.19 (0.08, 0.30)	6.9*10^-4
rs8101756	41502522	C/T	0.24	923	0.062 (-0.018, 0.14)	0.13
rs16974799	41504077	T/C	0.24	924	0.062 (-0.018, 0.14)	0.13
rs4803417	41508020	C/A	0.41	924	-0.21 (-0.28, -0.14)	4.9*10^-9
rs10500282	41508442	C/T	0.26	923	0.087 (0.009, 0.16)	0.028
rs11672911	41508744	A/G	0.32	924	0.17 (0.10, 0.25)	5.6*10^-6
rs2279345	41515702	T/C	0.39	924	-0.17 (-0.24, -0.10)	9.6*10^-7
rs8192718	41515814	A/G	0.02	924	-0.099 (-0.39, 0.19)	0.50
rs6508965	41517688	T/C	0.39	924	-0.17 (-0.24, -0.10)	1.1*10^-6
rs8192719	41518773	T/C	0.24	924	0.066 (-0.012, 0.14)	0.10
rs11882450	41520142	G/A	0.06	924	-0.095 (-0.24, 0.052)	0.20
rs11673270	41520844	C/A	0.24	924	0.060 (-0.019, 0.14)	0.14
rs7260329	41521638	A/G	0.32	924	0.17 (0.093, 0.24)	9. 3*10^-6
rs2291287	41522451	G/A	0.06	924	-0.095 (-0.24, 0.052)	0.20
rs1042389^c	41524153	G/A	0.21	923	0.040 (-0.041, 0.12)	0.33
rs1552223	41525952	G/A	0.39	924	-0.16 (-0.23, -0.092)	5.0*10^-6
rs2113103^c	41528667	A/G	0.15	924	0.076 (-0.018, 0.17)	0.11
rs7255904^c	41529020	A/G	0.45	921	0.13 (0.059, 0.19)	2.6*10^-4

^aSNP = single nucleotide polymorphisms.
^bMAF = Minor allele frequency.
^cSNPs genotyped in Uppsala, others in Oxford.
The position data originates from the UCSC Genome Browser on Human February 2009 (GRCh37/hg19) and allele data originates from the genotyped SNPs included in the study. All SNPs are located on chromosome 19.

ISSN: 1476-069X