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Table 4 Adjusted change in cortisol diurnal slope according to blood, tibia, and patella Pb concentrations in Mexico City women from 2007-2011 1

From: Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study

Pb biomarker/quantile

% Change in cortisol per 15 hours (95% CI)

β Coefficient (95% CI)

Blood Pb (n = 918) 2

  

Quintile 1 (0- < 1.8 µg/dL)

−77 (−79, −75)

Ref

Quintile 2 (1.8- < 2.4 µg/dL)

−77 (−79, −75)

0.00 (−0.06, 0.05)

Quintile 3 (2.4- < 3.4 µg/dL)

−76 (−78, −73)

0.03 (−0.03, 0.08)

Quintile 4 (3.4- < 5.1 µg/dL)

−76 (−78, −73)

0.02 (−0.03, 0.08)

Quintile 5 (≥5.1 µg/dL)

−78 (−79, −75)

−0.01 (−0.06, 0.05)

Continuous, per 2.5 µg/dL

N/A

0.00 (−0.02, 0.02)

Tibia Pb (n = 594) 3

  

Quantile 1 (<2 µg/g)

−77 (−79, −76)

Ref

Quantile 2 (2- < 4.3 µg/g)

−79 (−82, −76)

−0.05 (−0.11, 0.02)

Quantile 3 (4.3- < 6.7 µg/g)

−77 (−79, −73)

0.00 (−0.07, 0.07)

Quantile 4 (6.7- < 11.1 µg/g)

−77 (−80, −74)

−0.01 (−0.08, 0.06)

Quantile 5 (≥11.1 µg/g)

−74 (−78, −71)

0.04 (−0.03, 0.11)

Patella Pb (n = 587) 3

  

Quantile 1 (<2 µg/g)

−78 (−79, −76)

Ref

Quantile 2 (2- < 4.5 µg/g)

−77 (−80, −74)

−0.01 (−0.08, 0.05)

Quantile 3 (4.5- < 7.8 µg/g)

−77 (−80, −74)

−0.01 (−0.08, 0.05)

Quantile 4 (7.8- < 12.7 µg/g)

−79 (−81, −76)

−0.04 (−0.11, 0.03)

Quantile 5 (>12.7-43.2 µg/g)

−73 (−76, −69)

0.06 (−0.01, 0.12)

  1. 1-Only includes women who collected their first and second cortisol samples in the correct time window.
  2. 2-Salivary cortisol concentrations are modeled as a function of time since waking, Pb biomarker, a Pb biomarker x time interaction term, and covariates.
  3. 3-Adjusted for above covariates and maternal calf circumference at 1-month postpartum.