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Table 4 Adjusted change in cortisol diurnal slope according to blood, tibia, and patella Pb concentrations in Mexico City women from 2007-2011 1

From: Relationships between lead biomarkers and diurnal salivary cortisol indices in pregnant women from Mexico City: a cross-sectional study

Pb biomarker/quantile % Change in cortisol per 15 hours (95% CI) β Coefficient (95% CI)
Blood Pb (n = 918) 2   
Quintile 1 (0- < 1.8 µg/dL) −77 (−79, −75) Ref
Quintile 2 (1.8- < 2.4 µg/dL) −77 (−79, −75) 0.00 (−0.06, 0.05)
Quintile 3 (2.4- < 3.4 µg/dL) −76 (−78, −73) 0.03 (−0.03, 0.08)
Quintile 4 (3.4- < 5.1 µg/dL) −76 (−78, −73) 0.02 (−0.03, 0.08)
Quintile 5 (≥5.1 µg/dL) −78 (−79, −75) −0.01 (−0.06, 0.05)
Continuous, per 2.5 µg/dL N/A 0.00 (−0.02, 0.02)
Tibia Pb (n = 594) 3   
Quantile 1 (<2 µg/g) −77 (−79, −76) Ref
Quantile 2 (2- < 4.3 µg/g) −79 (−82, −76) −0.05 (−0.11, 0.02)
Quantile 3 (4.3- < 6.7 µg/g) −77 (−79, −73) 0.00 (−0.07, 0.07)
Quantile 4 (6.7- < 11.1 µg/g) −77 (−80, −74) −0.01 (−0.08, 0.06)
Quantile 5 (≥11.1 µg/g) −74 (−78, −71) 0.04 (−0.03, 0.11)
Patella Pb (n = 587) 3   
Quantile 1 (<2 µg/g) −78 (−79, −76) Ref
Quantile 2 (2- < 4.5 µg/g) −77 (−80, −74) −0.01 (−0.08, 0.05)
Quantile 3 (4.5- < 7.8 µg/g) −77 (−80, −74) −0.01 (−0.08, 0.05)
Quantile 4 (7.8- < 12.7 µg/g) −79 (−81, −76) −0.04 (−0.11, 0.03)
Quantile 5 (>12.7-43.2 µg/g) −73 (−76, −69) 0.06 (−0.01, 0.12)
  1. 1-Only includes women who collected their first and second cortisol samples in the correct time window.
  2. 2-Salivary cortisol concentrations are modeled as a function of time since waking, Pb biomarker, a Pb biomarker x time interaction term, and covariates.
  3. 3-Adjusted for above covariates and maternal calf circumference at 1-month postpartum.
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Environmental Health

ISSN: 1476-069X