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Table 5 Correlation between the incidence of mesothelioma in rats and in vitro cytotoxicity or initiation of abnormal anaphase/telophase in cultures of rat pleural mesothelial cells * [[87]]

From: Quantification of short and long asbestos fibers to assess asbestos exposure: a review of fiber size toxicity

 

Probability of mesothelioma induction based on:

Metric

Cytotoxicity (IC75)

Abnormal mitosis

Weight

0.16

0.27

Total fibers

0.56

0.14

“Stanton” fibers

0.84

0.0075

“Pott” fibers

ND

0.14

Fibers > 4 μm in length

ND

0.25

  1. *Rank Spearman test.
  2. ND: not determined.
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Environmental Health

ISSN: 1476-069X