Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study

Table 2 Maternal genotype frequencies and geometric mean blood lead levels for dominant models ^a,b

Single-nucleotide polymorphism	No.	Genotype frequencies	Dominant modeling	Geometric mean BLL^c(95% CI^d)
TF P570S (rs1049296)
Homozygous wild-type	355	CC = 0.75	wild-type	0.62 (0.58, 0.66)
Heterozygous	109	CT = 0.23	variant	0.60 (0.55, 0.67)
Homozygous variant	12	TT = 0.02	variant	0.60 (0.55, 0.67)
HFE H63D (rs1799945)
Homozygous wild-type	350	HH = 0.74	wild-type	0.61 (0.57, 0.65)
Heterozygous	117	HD = 0.24	variant	0.62 (0.56, 0.69)
Homozygous variant	9	DD = 0.02	variant	0.62 (0.56, 0.69)
HFE C282Y (rs1800562)
Homozygous wild-type	417	CC = 0.88	wild-type	0.62 (0.58, 0.65)
Heterozygous	55	CY = 0.11	variant	0.60 (0.51, 0.70)
Homozygous variant	4	YY = 0.01	variant	0.60 (0.51, 0.70)

^aAll genotype frequencies are in Hardy-Weinberg equilibrium (α = 0.05); ^bNone of the differences in geometric mean BLL by variant status are statistically significant; ^cblood lead level (μg/dL); ^dconfidence interval.

ISSN: 1476-069X