Maternal iron metabolism gene variants modify umbilical cord blood lead levels by gene-environment interaction: a birth cohort study

Table 3 Infant genotype frequencies and geometric mean umbilical cord blood lead levels for dominant models ^a,b

Single-nucleotide polymorphism	No.	Genotype frequencies	Dominant modeling	Geometric mean BLL^c(95% CI^d)
TF P570S (rs1049296)
Homozygous wild-type	338	CC = 0.71	wild-type	0.43 (0.40, 0.47)
Heterozygous	129	CT = 0.27	variant	0.40 (0.36, 0.46)
Homozygous variant	9	TT = 0.02	variant	0.40 (0.36, 0.46)
HFE H63D (rs1799945)
Homozygous wild-type	330	HH = 0.69	wild-type	0.44 (0.40, 0.48)
Heterozygous	132	HD = 0.28	variant	0.39 (0.35, 0.44)
Homozygous variant	14	DD = 0.03	variant	0.39 (0.35, 0.44)
HFE C282Y (rs1800562)
Homozygous wild-type	415	CC = 0.87	wild-type	0.42 (0.39, 0.46)
Heterozygous	58	CY = 0.12	variant	0.43 (0.36, 0.51)
Homozygous variant	3	YY = 0.01	variant	0.43 (0.36, 0.51)

^aAll genotype frequencies are in Hardy-Weinberg equilibrium (α = 0.05); ^bNone of the differences in geometric mean BLL by variant status are statistically significant; ^cblood lead level (μg/dL); ^dconfidence interval.

ISSN: 1476-069X