Figure 4

Effects of test samples on infiltration of inflammatory cells in the airway. (A) Control, (B) Tar 1, (C) Tar 5: no pathological changes in lungs treated with saline, Tar 1 and Tar 5. (D) OVA alone: slight infiltration of eosinophils, neutrophils and lymphocytes into the airway submucosa. (E) OVA + Tar 1, (F) OVA + Tar 5, (G) H-ASD + OVA: slight to mild infiltration of inflammatory cells into the airway submucosa. (H) H-ASD + OVA + Tar 1: marked accumulation of eosinophils, neutrophils and lymphocytes in the airway submucosa. (I) H-ASD + OVA + Tar 5: moderate infiltration of these inflammatory cells into the submucosa of airways. (A–I) HE stain; bar = 20 μm.