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Figure 2 | Environmental Health

Figure 2

From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Figure 2

Mechanism of the NMDR relationship phenomenon induced by the “plurality of molecular targets”. At low concentrations, EDC binds to the A receptors and induces the observed effect. At high concentrations, the A receptors are still activated and EDC binds to the B receptors, which induces the opposite effect, resulting in an NMDR. Notes: A = Receptor A; B = Receptor B; xe = xenobiotic (e.g., EDC); affinity for A > B.

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