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Figure 5 | Environmental Health

Figure 5

From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Figure 5

Mechanism of the NMDR relationship phenomenon induced by the “mixed-ligand” hypothesis. At low concentrations, the EDC binds to the hormone receptor and forms mixed-ligand dimers that block endogenous hormone activity. At high concentrations, dimers of EDCs are more likely to form and induce a response. Note: H = endogenous hormone; R = hormone receptor; xe = xenobiotic (e.g., EDC).

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Environmental Health

ISSN: 1476-069X