Mechanistic hypotheses | References |
---|---|
Existence of several molecular targets with different affinities and opposite effects | [6, 16, 18, 19, 24, 26–28, 34, 38, 42, 43, 45–47, 50, 54, 55, 57, 58, 60, 61, 63] |
Negative feedback phenomenon | |
High-dose receptor desensitization | |
Dose-dependent metabolism modulation | |
High-dose toxicity | |
Dose-dependent protein ionization | [35] |