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Table 6 Mechanistic hypotheses reported in corresponding studies

From: Non-monotonic dose-response relationships and endocrine disruptors: a qualitative method of assessment

Mechanistic hypotheses References
Existence of several molecular targets with different affinities and opposite effects [6, 16, 18, 19, 24, 2628, 34, 38, 42, 43, 4547, 50, 54, 55, 57, 58, 60, 61, 63]
Negative feedback phenomenon [6, 25, 31, 36, 47, 50, 57, 58, 60, 61, 63]
High-dose receptor desensitization [25, 44, 52]
Dose-dependent metabolism modulation [16, 38]
High-dose toxicity [41, 47, 49]
Dose-dependent protein ionization [35]