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Table 4 Association of pyridostigmine bromide use with chronic illness in BChE subgroups: evaluation using two case definitions

From: Butyrylcholinesterase genotype and enzyme activity in relation to Gulf War illness: preliminary evidence of gene-exposure interaction from a case–control study of 1991 Gulf War veterans

 

Use of PB by all Gulf War veterans (n = 304)

Use of PB by butyrylcholinesterase genetic subgroups

Common BChE variants (U/U and U/K) (n = 276)

Less common BChE variants (K/K, U/AK, U/A, A/F, AK/F) (n = 28)

Case definition

% cases exposed

% controls exposed

OR (95% C.I.)

% cases exposed

% controls exposed

OR (95% C.I.)

% cases exposed

% controls exposed

OR (95% C.I.)

GWI (Kansas case definition)*

72%

44%

3.21 (1.97–5.24)

69%

46%

2.68 (1.62–4.44)

92%

23%

40.00 (3.58–447)

CMI (CDC case definition)↑

63%

46%

1.99 (1.23–3.22)

62%

49%

1.73 (1.05–2.84)

78%

22%

11.37 (1.65–78.4)

  1. BChE = butyrylcholinesterase, PB = pyridostigmine bromide, CDC = U.S. Centers for Disease Control and Prevention, OR = prevalence odds ratio, C.I. = confidence interval.
  2. *Gulf War illness, as defined in Steele [1].
  3. ↑Chronic multisymptom illness, as defined in Fukuda et al. [32].
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Environmental Health

ISSN: 1476-069X