Biomarker analysis of Fraction-1 from PCB-exposed pregnant women. Serum samples (n = 211) from the Faroese cohort were separated on HPLC, followed by E-Screen analysis of the reconstituted Fr-1 in the absence (A) or presence (B) of 10 pM E2. Subfractions s4 and s8 was removed before E-Screen analysis. Results are expressed as the relative proliferative effect (RPE) to E2. Values shown are mean ± SD from triplicate wells. The broken line represents the background of the experimental series (the mean of negative controls + 3x SD).