|
Compound
|
Rt
|
MOEC
|
RPP
|
|---|
| | |
μM
|
RPE ± SD
| |
|---|
|
Endogenous compounds
|
|
Cholesterol
|
1.83
|
0.0001–10
|
Nonactive
|
-
|
|
5α-dihydroprogesterone
|
4.14
|
10
|
58 ± 3
|
0.01
|
|
Progesterone
|
5.03
|
25
|
16 ± 2
|
0.004
|
|
Pregnenolone
|
6.07
|
10
|
92 ± 6
|
0.01
|
|
Androsterone
|
6.21
|
10
|
97 ± 3
|
0.01
|
|
5α-dihydrotestosterone
|
6.63
|
1
|
64 ± 5
|
0.1
|
|
Androstenedione
|
6.80
|
10
|
16 ± 2
|
0.01
|
|
Dehydroepiandrosterone
|
6.86
|
1
|
92 ± 2
|
0.1
|
|
Testosterone
|
8.23
|
10
|
34 ± 5
|
0.01
|
|
Estrone
|
9.06
|
0.01
|
84 ± 8
|
10
|
|
17α-hydroxyprogesterone
|
9.23
|
10
|
7 ± 1
|
0.01
|
|
17α-hydroxypregnenolone
|
12.78
|
10
|
30 ± 1
|
0.01
|
|
17β-estradiol
|
14.83
|
0.001
|
100 ± 7
|
100
|
|
16α-hydroxyestrone
|
22.86
|
0.01
|
77 ± 2
|
10
|
|
Estriol
|
24.01
|
0.01
|
103 ± 3
|
10
|
|
Organochlorines
|
|
Hexachlorobenzene
|
1.34
|
0.001 – 50
|
Nonactive
|
-
|
|
PCB180
|
1.40
|
0.001 – 50
|
Nonactive
|
-
|
|
p,p'-DDE
|
1.43
|
12.5
|
92 ± 2
|
0.008
|
|
PCB153
|
1.48
|
0.001 – 50
|
Nonactive
|
-
|
|
PCB138
|
1.49
|
0.001 – 50
|
Nonactive
|
-
|
|
o,p'-DDT
|
1.53
|
6.25
|
96 ± 7
|
0.016
|
|
Dieldrin
|
1.75
|
25
|
44 ± 9
|
0.004
|
|
Methoxychlor
|
2.29 + 2.88
|
12.5
|
57 ± 8
|
0.008
|
|
4-OH-CB146
|
2.67
|
0.001 – 50
|
Nonactive
|
-
|
|
4-OH-CB187
|
2.67
|
50
|
24 ± 4
|
0.002
|
|
4-OH-CB107
|
2.70
|
0.001 – 50
|
Nonactive
|
-
|
|
β-hexachlorocyclohexane
|
4.13
|
2.5
|
61 ± 2
|
0.04
|
- Abbreviations: Rt, retention time; MOEC, maximum observed effect concentration; RPE, relative proliferative effect; RPP, relative proliferative potency
