Figure 1

(A) Results from a sensitivity analysis conducted to determine the stability of the main effect of tube well arsenic concentration in 50 ug/L intervals on the odds ratio for developing skin lesions. (B) Results from a sensitivity analysis conducted to determine the stability of the main effect of GSTT1 genotype on the odds ratio for developing skin lesions. (C). Results from a sensitivity analysis conducted to determine the stability of the main effect of GSTM1 on the odds for developing skin lesions. (D) Results from a sensitivity analysis conducted to determine the stability of the main effect of GSTP1 GG allele on the odds for developing skin lesions. (E) Results from a sensitivity analysis conducted to determine the stability of the main effect of GSTP1 AG allele on the odds for developing skin lesions. The sensitivity analysis evaluated the influence of control selection allowing for 70–95% of the controls being selected from tube wells containing less than 50 ug/L. The black line represents the sampling design employed in this study which assumed that the 80% of the tube wells in Pabna contained arsenic concentrations below 50 ug/L. As the percentage of controls with arsenic concentrations below 50 ug/L increases, the OR for skin lesions increases associated with each 50 μg/l increase in tube well arsenic. The X-axis is the percentage of controls selected from areas suspected to have well water arsenic concentration less than 50 μg/l. Odds ratios and 95% CI are graphed to show the stability of the effect estimates as the percentage of controls from low exposure areas are varied in the logistic regression model.