Table 3 Association of the CRS score (CRS ≤ 20; CRS > 20) with NAT2, GSTM1, GSTP1 and GSTT1.

*4/*4

15 (6.0)

13 (4.8)

1.00^d

1.00^d

*4/*5

68 (27.4)

49 (17.9)

0.83 (0.36–1.90)

0.83 (0.36–1.92)

0.668

*4/*6

39 (15.7)

34 (12.5)

1.01 (0.42–2.41)

0.97 (0.40–2.33)

0.937

*4/*7

3 (1.2)

5 (1.8)

1.92 (0.38–9.65)

1.88 (0.37–9.47)

0.446

*5/*5

49 (19.8)

61 (22.3)

1.44 (0.62–3.30)

1.51 (0.65–3.50)

0.339

*5/*6

56 (22.6)

74 (27.1)

1.52 (0.67–3.46)

1.57 (0.69–3.60)

0.286

*5/*7

4 (1.6)

5 (1.8)

1.44 (0.32–6.53)

1.46 (0.32–6.71)

0.627

*6/*6

14 (5.6)

31 (11.4)

2.55 (0.96–6.77)

2.56 (0.95–6.89)

0.062

*6/*7

-

1 (0.4)

n.c.^e

n.c.^e

-

*7/*7

-

-

-

-

-

all

125 (50.4)

101 (37.0)

1.00^d

1.00^d

all

123 (49.6)

172 (63.0)

1.73 (1.22–2.46)

1.81 (1.27–2.59)

0.001

*1/*1 or *0/*1

143 (57.7)

109 (39.9)

1.00^d

1.00^d

*0/*0

105 (42.3)

164 (60.1)

2.05 (1.44–2.91)

2.08 (1.46–2.96)

0.0001

*1/*1 or *0/*1

226 (91.1)

214 (78.4)

1.00^d

1.00^d

*0/*0

22 (8.9)

59 (21.6)

2.83 (1.68–4.78)

2.80 (1.65–4.75)

0.0001

*A/*A

106 (42.7)

117 (42.9)

1.00^d

1.00^d

*A/*B

82 (33.1)

101 (37.0)

1.12 (0.75–1.65)^e

1.17 (0.79–1.75)^e

0.433

*A/*C or *B/*D

29 (11.7)

20 (7.3)

*A/*D

2 (0.8)

5 (1.8)

*B/*B

21 (8.5)

22 (8.1)

*B/*C

5 (2.0)

7 (2.6)

*C/*C

3 (1.2)

1 (0.4)

*C/*D

-

-

*D/*D

-

-

all except *A/*A

142 (57.3)

156 (57.1)

1.00 (0.70–1.41)

1.04 (0.73–1.48)

0.83