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Table 1 Characteristics of the study subjectsa.

From: Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study

   Exposed workers Non-exposed workers
   N % N %
Sexb** Male/Female 107/25 81/19 55/59 48/52
Smoker No+Former/Yes 77/52 60/40 71/42 63/37
Atopy Negative/Positive 94/37 72/28 82/31 73/27
SYMPTOMS      
Eye symptomsb** No/Yes 71/57 55/45 89/25 78/22
Wheeze etc. No/Yes 88/41 68/32 90/24 79/21
Dry coughb** No/Yes 88/39 69/31 101/13 89/11
Cough with mucus No/Yes 84/44 66/34 87/27 76/24
Nose bleedb** No/Yes 96/28 78/23 107/7 94/6
GENOTYPES/PHENOTYPES      
GSTM1 +/- 65/67 49/51 65/49 57/43
GSTT1 +/- 110/22 83/17 97/17 85/15
GSTM3 AA/AB/BB 94/36/2 71/27/2 78/31/5 68/27/4
GSTP1* 105 II/IV/VV 68/51/13 52/39/10 57/46/11 50/40/10
GSTP1* 114 AA/AV 114/18 86/14 103/11 90/10
GSTP1* 105 +114 A/B/C 68/46/18 51/35/14 57/46/11 50/40/10
NAT1 phenotype S/IM/R 3/88/41 2/67/31 3/76/35 3/67/30
NAT2 phenotype S/IM/R 89/33/10 67/25/8 73/38/3 64/33/3
MPO b** GG/GA/AA 97/29/6 73/22/5 74/40/0 65/35/0
SULT1A1 GG/GA/AA 43/77/12 33/58/9 46/54/14 40/47/12
CYP1A1*2A A/B/C 116/14/2 88/11/2 97/16/1 85/14/1
CYP1A1*2B AA/AG/GG 126/5/1 95/4/1 107/7/0 94/6/0
TNF-308 GG/GA/AA 83/35/4 68/29/3 69/35/5 63/32/5
TNF-863 CC/CA/AA 93/28/6 73/22/5 78/32/2 70/29/2
CCL5 GG/GA/AA 84/38/5 66/30/4 72/36/4 64/32/4
HLA-DQB1*05 -/+ 88/39 69/31 87/25 78/22
HLA-DQB1*0501b* -/+ 98/29 77/23 98/14 88/12
HLA-DQB1*0502 -/+ 118/9 93/7 105/7 94/6
HLA-DQB1*0503 -/+ 125/2 98/2 108/4 96/4
HLA-DQB1*0504 -/+ 126/1 99/1 112/0 100/0
  1. aData was incomplete for some individuals studied, but these study subjects were included in the analyses when possible. Due to variations in success rate of the genotype analyses, the number of analyzed individuals differs to some extent between the different polymorphisms. Moreover, all 246 individuals approved analysis of metabolizing genes, whereas 239 individuals approved analysis of immune-related genes.
  2. bStatistically significant differences between exposed and non-exposed workers.
  3. *p < 0.05, **p < 0.01.