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Table 2 Symptoms of the eyes and airways comparing different genotypes among TDI-exposed and non-exposed workers.a

From: Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study

   Geno-type Symptoms    
    Yes (N) No (N) ORb 95% CI Pc*
EYES
Exposed NAT1 IM+S 33 53 1.0 - 0.067
   R 23 17 2.2 1.0–4.9  
Unexposed NAT1 IM+S 19 60 1.0 -  
   R 6 27 0.63 0.22–1.9  
Exposed SULT1A1 R213H GG 27 14 1.0 - 0.19
   AG+AA 29 56 0.22 0.096–0.52  
Unexposed SULT1A1 R213H GG 13 31 1.0   
   AG+AA 12 56 0.56 0.22–1.4  
Exposed TNF -308 GG 36 44 1.0 - 0.11
   GA+AA 17 19 1.0 0.47–2.4  
Unexposed TNF -308 GG 11 57 1.0 -  
   GA+AA 14 25 2.6 1.0–7.0  
WHEEZE
Exposed CYP1A1 *2B I/I 34 87 1.0 - 0.061
   I/V 5 1 14 1.5–130  
Unexposed CYP1A1 *2B I/I 23 82 1.0 -  
   I/V 1 6 0.83 0.090–7.7  
Exposed SULT1A1 R213H GG 17 25 1.0 - 0.58
   AG+AA 22 63 0.52 0.22–1.2  
Unexposed SULT1A1 R213H GG 14 30 1.0 -  
   AG+AA 10 58 0.38 0.15–0.99  
Exposed CCL5 -403 GG 19 64 1.0 - 0.42
   AG+AA 20 21 3.1 1.3–7.1  
Unexposed CCL5 -403 GG 13 58 1.0 -  
   AG+AA 10 29 1.8 0.68–5.0  
Exposed TNF -308 GG 29 52 1.0 - 0.043
   GA+AA 7 30 0.37 0.14–0.99  
Unexposed TNF -308 GG 13 55 1.0 -  
   GA+AA 10 29 1.3 0.46–3.4  
DRY COUGH
Exposed HLADQB1 *05 Absent 20 62 1.0 - 0.047
   Present 18 20 2.7 1.2–6.3  
Unexposed HLADQB1 *05 Absent 12 74 1.0 -  
   Present 1 23 0.27 0.031–2.2  
Exposed TNF -308 GG 30 50 1.0 - 0.023
   GA+AA 7 28 0.43 0.17–1.1  
Unexposed TNF -308 GG 6 62 1.0 -  
   GA+AA 7 32 2.2 0.66–7.3  
COUGH WITH MUCUS
Exposed GSTM1 Present 19 45 1.0 - 0.13
   Absent 24 39 1.4 0.66–3.0  
Unexposed GSTM1 Present 8 55 1.0 -  
   Absent 18 31 3.5 1.3–9.4  
Exposed GSTM3 AA 29 61 1.0 - 0.028
   AB+BB 14 23 1.2 0.52–2.7  
Unexposed GSTM3 AA 23 53 1.0 -  
   AB+BB 3 33 0.22 0.059–0.81  
Exposed GSTP1 *105 I/I 26 41 1.0 - 0.019
   I/V+V/V 17 43 0.66 0.32–1.4  
Unexposed GSTP1 *105 I/I 8 48 1.0 -  
   I/V+V/V 18 38 3.0 1.1–8.0  
Exposed CCL5 -403 GG 22 59 1.0 - 0.079
   AG+AA 21 20 2.9 1.3–6.5  
Unexposed CCL5 -403 GG 17 54 1.0 -  
   AG+AA 8 31 0.86 0.32–2.3  
NOSE BLEED
Exposed MPO GG 25 65 1.0 - 0.018
   AG+AA 3 30 0.21 0.056–0.94  
Unexposed MPO GG 3 70 1.0 -  
   AG+AA 4 35 2.9 0.58–14  
  1. a Adjusted effect estimates (for sex, age, atopy, and smoking) are presented as odds ratios (OR) and 95% confidence intervals. Statistically significant results are presented in bold.
  2. bAll results that reached statistical significance with respect to genotype-associated risk in either exposure-strata, or in the analysis of interaction between genotype and exposure status, are presented.
  3. cAnalysis of interaction between exposure and genotype was performed in a separate model using logistic regression with interaction term. P-values regarding interaction between exposure and genotype are indicated by P*.