Skip to main content

Table 2 Symptoms of the eyes and airways comparing different genotypes among TDI-exposed and non-exposed workers.a

From: Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study

  

Geno-type

Symptoms

   
   

Yes (N)

No (N)

ORb

95% CI

Pc*

EYES

Exposed

NAT1

IM+S

33

53

1.0

-

0.067

  

R

23

17

2.2

1.0–4.9

 

Unexposed

NAT1

IM+S

19

60

1.0

-

 
  

R

6

27

0.63

0.22–1.9

 

Exposed

SULT1A1 R213H

GG

27

14

1.0

-

0.19

  

AG+AA

29

56

0.22

0.096–0.52

 

Unexposed

SULT1A1 R213H

GG

13

31

1.0

  
  

AG+AA

12

56

0.56

0.22–1.4

 

Exposed

TNF -308

GG

36

44

1.0

-

0.11

  

GA+AA

17

19

1.0

0.47–2.4

 

Unexposed

TNF -308

GG

11

57

1.0

-

 
  

GA+AA

14

25

2.6

1.0–7.0

 

WHEEZE

Exposed

CYP1A1 *2B

I/I

34

87

1.0

-

0.061

  

I/V

5

1

14

1.5–130

 

Unexposed

CYP1A1 *2B

I/I

23

82

1.0

-

 
  

I/V

1

6

0.83

0.090–7.7

 

Exposed

SULT1A1 R213H

GG

17

25

1.0

-

0.58

  

AG+AA

22

63

0.52

0.22–1.2

 

Unexposed

SULT1A1 R213H

GG

14

30

1.0

-

 
  

AG+AA

10

58

0.38

0.15–0.99

 

Exposed

CCL5 -403

GG

19

64

1.0

-

0.42

  

AG+AA

20

21

3.1

1.3–7.1

 

Unexposed

CCL5 -403

GG

13

58

1.0

-

 
  

AG+AA

10

29

1.8

0.68–5.0

 

Exposed

TNF -308

GG

29

52

1.0

-

0.043

  

GA+AA

7

30

0.37

0.14–0.99

 

Unexposed

TNF -308

GG

13

55

1.0

-

 
  

GA+AA

10

29

1.3

0.46–3.4

 

DRY COUGH

Exposed

HLADQB1 *05

Absent

20

62

1.0

-

0.047

  

Present

18

20

2.7

1.2–6.3

 

Unexposed

HLADQB1 *05

Absent

12

74

1.0

-

 
  

Present

1

23

0.27

0.031–2.2

 

Exposed

TNF -308

GG

30

50

1.0

-

0.023

  

GA+AA

7

28

0.43

0.17–1.1

 

Unexposed

TNF -308

GG

6

62

1.0

-

 
  

GA+AA

7

32

2.2

0.66–7.3

 

COUGH WITH MUCUS

Exposed

GSTM1

Present

19

45

1.0

-

0.13

  

Absent

24

39

1.4

0.66–3.0

 

Unexposed

GSTM1

Present

8

55

1.0

-

 
  

Absent

18

31

3.5

1.3–9.4

 

Exposed

GSTM3

AA

29

61

1.0

-

0.028

  

AB+BB

14

23

1.2

0.52–2.7

 

Unexposed

GSTM3

AA

23

53

1.0

-

 
  

AB+BB

3

33

0.22

0.059–0.81

 

Exposed

GSTP1 *105

I/I

26

41

1.0

-

0.019

  

I/V+V/V

17

43

0.66

0.32–1.4

 

Unexposed

GSTP1 *105

I/I

8

48

1.0

-

 
  

I/V+V/V

18

38

3.0

1.1–8.0

 

Exposed

CCL5 -403

GG

22

59

1.0

-

0.079

  

AG+AA

21

20

2.9

1.3–6.5

 

Unexposed

CCL5 -403

GG

17

54

1.0

-

 
  

AG+AA

8

31

0.86

0.32–2.3

 

NOSE BLEED

Exposed

MPO

GG

25

65

1.0

-

0.018

  

AG+AA

3

30

0.21

0.056–0.94

 

Unexposed

MPO

GG

3

70

1.0

-

 
  

AG+AA

4

35

2.9

0.58–14

 
  1. a Adjusted effect estimates (for sex, age, atopy, and smoking) are presented as odds ratios (OR) and 95% confidence intervals. Statistically significant results are presented in bold.
  2. bAll results that reached statistical significance with respect to genotype-associated risk in either exposure-strata, or in the analysis of interaction between genotype and exposure status, are presented.
  3. cAnalysis of interaction between exposure and genotype was performed in a separate model using logistic regression with interaction term. P-values regarding interaction between exposure and genotype are indicated by P*.
Back to article page

Environmental Health

ISSN: 1476-069X