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Table 2 Annual medical check examination sheet of Yusho patients

From: Association of clinical findings in Yusho patients with serum concentrations of polychlorinated biphenyls, polychlorinated quarterphenyls and 2,3,4,7,8-pentachlorodibenzofuran more than 30 years after the poisoning event

(1). Laboratory examination

Blood concentrations of PCB- and dioxin-related compounds

   Total PCB, Peak 1, Peak 2, Peak 3, PCB pattern, CB ratio, Total PCQ, Dioxin-related compounds

   Urinalysis (Protein, Sugar, Occult blood, Urobilinogen, pH)

Hematological examination

   ESR (1-hour), ESR (2-hour), WBC, RBC, Hb, Ht, MCV, MCH, MCHC, PLT

Blood chemistry

   T-Bil, D-Bil, GOT, GPT, TP, Alb, albumin/globulin(A/G) ratio, ZTT, TTT, ALP, LAP, γ-GTP, ChE, LDH,

   CPK, TC, HDL-chol, TG, β-lip, BUN, Cre, Na, K, Ca, P, Amy, blood sugar level

Immunological examination (HBs antigen, α-fetoprotein)

(2). Interview and physical examination

Life history (Alcohol, Smoking)

Chief complaint

Past history(Before the incident, After the incident)

Subjective symptoms

   General fatigue, Headache, Cough, Sputum, Abdominal pain, Diarrhea, Constipation

   Numbness, Arthralgia, menstruation disorders

Physical examination

   Body height, Body weight, Heart rate, Blood pressure, Nutrition, Heart sounds, Respiratory sounds,

   Chest radiography, ECG, Abdominal ultrasonography,

   Hepatomegaly, Splenomegaly, Edema, Lymphadenopathy, Tendon reflex, Sensory examination,

(3). Dermatological examination

Interview

   Recent tendency to purulent skin eruptions, Recent recurrence of cystic lesions,

   Past history of acneform eruptions, Past history of pigmentation,

Physical examination (severity and sites)

   Black comedones, Acneform eruptions, Scar formation, Pigmentation, Nail deformity,

(4). Dental examination

Chief complaint

   Toothache, Gingival bleeding, Pus discharge, Gingival swelling, Feeling of tooth extrusion, Pigmentation

Items for oral examination (No/Yes, site)

   Gingivitis, Marginal periodontitis, Retarded eruptions of permanent teeth,

   Tooth pigmentation, Odontogenesis imperfecta, Abnormal occlusion, Other findings,

Mucosal pigmentation (severity, site, *pattern, **color)

   Upper gingivae, Lower gingivae, Rt. buccal mucosa, Lt. buccal mucosa, Palate,

   Upper lip, Lower lip

Teeth radiograph (No/Yes)

   *Selection items for pattern (Diffuse, Spotted, Band-like, Linear, Faint, Scattered)

   **Selection items for color (Black, Brownish, Dark-brownish)

(5). Ophthalmological examination

Subjective symptoms (Abnormal discharge from the eyes)

Objective symptoms

   Edema of the eyelid, Conjunctival pigmentation, Cysts of meibomian glands,

   Cheesy secretion from meibomian glands,