Potential developmental neurotoxicity of pesticides used in Europe

Table 1 Neurotoxic pesticides, which are authorised or pending evaluation for authorisation in the EU

Pesticide	Annex 1 status
Organophosphate insecticides
Chlorpyrifos	In
Dimethoate	In
Ethoprophos	In
Phosmet	In
Fenamiphos (nematicide)	In
Carbamates
Pirimicarb	In
Methomyl	Application resubmitted
Pyrethroid insecticides
Cypermethrin (type II)	In
Deltamethrin (type II)	In
Pyrethrum/pyrethrin (natural pyrethrin)	Pending
Other insecticides
Nicotine	Pending
Dithiocarbamate fungicides
Maneb	In
Thiram	In
Chlorophenoxy herbicides
2,4-D	In
Bipyridyl herbicides
Diquat dibromide	In
Rodenticides
Warfarin	In
Fumigants
Phosphides (zinc, magnesium, and aluminum phosphides)	Pending
Sulfuryl fluoride	Pending

The list includes pesticicides, which are registered as "in" or "pending" on the current EU Annex 1 list (as of August 2008), and for which neurotoxicity in humans has been reported in The Hazardous Substances Data Bank and/or the NIOSH Pocket Guide to Chemical Hazards. The full Annex 1 list with the status of active substances under EU review can be downloaded as an Excel sheet at http://ec.europa.eu/food/plant/protection/pesticides/index_en.print.htm.

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