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Table 9 Toxic effects of mercury on various cell lines.

From: Feeding mice with diets containing mercury-contaminated fish flesh from French Guiana: a model for the mercurial intoxication of the Wayana Amerindians

Organisms and species Cell types Mercury effects Ref.
Bacteria Escherichia coli Strains devoid of R plasmids Growth inhibition: MIC = 11.5 μM HgCl2. [45]
Yeast Saccharomyces cerevisiae Strain W303B Growth inhibition: MIC = 2 μM MeHgCl at 24 h. [46]
Clam Mya arenaria Hemocytes Phagocytosis inhibition: IC50 = 0.44 μM MeHgCl at 18 h. [47]
Earthworm Lumbricus terrestris Coelomocytes Phagocytosis inhibition: IC50 = 0.1 μM MeHgCl and 0.5 μM HgCl2 at 18 h. [48]
Mosquito Aedes albopictus Cell line C6/36 Cell viability: for serum deprived cultures, LD50 = 2.1 μM MeHgCl and 2.5 μM HgCl2 at 24 h; for cultures with fetal calf serum, LD50 = 5.5 μM MeHgCl and 12 μM HgCl2 at 24 h.
Cell growth inhibition: IC50 = 1 μM MeHgCl and 18.4 μM HgCl2 at 18 days.
[49]
Chicken Retinal cells Cell viability: 49% cell death with 10 μM MeHgCl at 6 h. [50]
Fish fathead minnow CCL-42 Cell viability: EC50 = 1.55 μM MeHgOH at 96 h. [51]
Rabbit Renal proximal tubule cells Cell viability: LC50 = 6.1 μM MeHgCl and 34.2 μM HgCl2 at 24 h. [52]
Rat Cerebellar granule cells 50% apoptotic cells with 1 μM MeHgCl for 9 h; 30% apoptotic cells and 60% reduction in mitochondrial dehydrogenases with 2.5 μM MeHgCl for 1 h. [31]
Rat Embryonic neural stem cells 90% cell death with 0.5 μM MeHgCl for 24 h; 37% apoptotic cells with 0.1 μM MeHgCl for 24 h. [53]
Rat Splenocytes
Leukocytes
Cytolethality: 8 μM MeHgCl for 24 h. [54]
Mouse Cerebellar neurons 50% reduction in mitochondrial activity with 5 μM MeHgCl for 1 h. [32]
  Cerebellar astrocytes 40% reduction in mitochondrial activity with 5 μM MeHgCl for 1 h.  
Mouse Macrophages Cell death: 20 μM MeHgCl for a few days. [55]
Mouse Peritoneal neutrophils Necrotic cell death: 15 μM MeHgCl for 13 min. [56]
Mouse Multipotent neural stem cell line C17.2 45% cell death with 2 μM MeHgCl at 24 h; 20% apoptotic cells with 0.5 μM at 24 h. [53]
Man YAC-1 murine Moloney virus transformed lymphoma cell line 50% cell death with 25 μM MeHgCl at 4 h. [57]
Man T lymphocytes Cell viability: 8 μM MeHgCl at 24 h. [58]
  Monocytes Cell viability: 8 μM MeHgCl at 4 h.  
Man Neurons Cell viability: LC50 = 6.5 μM MeHgCl at 24 h. [59]
  Astrocytes Cell viability: LC50 = 8.1 μM MeHgCl at 24 h.  
  Neuroblastoma cells Cell viability: LC50 = 6.9 μM MeHgCl at 24 h.  
  1. Ref.: references; EC50 : median effective concentration; HgCl2 : mercury chloride; IC50 : median inhibitory concentration; LC50 : median lethal concentration; LD50 : median lethal dose; MeHgCl: methylmercury chloride; MeHgOH: methylmercury hydroxide; MIC: minimal inhibitory concentration.