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Table 2 NBEs for MP and EP in urine derived from model simulations of an exposure to a NOEL under different scenarios likely to occur in children

From: Determination of no-observed effect level (NOEL)-biomarker equivalents to interpret biomonitoring data for organophosphorus pesticides in children

Exposure scenario used to derive the NBEs Proposed NBE for methylphosphates in 12-h nighttime urine collectionsa
(nmol/kg bw)
Proposed NBE for ethylphosphates in 12-h nighttime urine collectionsb
(nmol/kg bw)
Ingestion of a bolus NOEL at dinnerc 106 87
Ingestion of 1/3 NOEL at each meald 127 52
8-h Dermal exposure to the NOELe 40 32
  1. a Corresponds to the total amounts of methylphosphate metabolites in 12-h nighttime collections (from 7:00 pm to 7:00 am) following different simulated NOEL exposure scenarios.
  2. b Corresponds to the total amounts of ethylphosphate metabolites in 12-h nighttime collections (from 7:00 pm to 7:00 am) following different simulated NOEL exposure scenarios.
  3. c Simulation of an oral exposure to the NOEL of either malathion or chlorpyrifos at 6:00 pm.
  4. d Simulation of an oral exposure to 1/3 of the NOEL of either malathion or chlorpyrifos at 7:00 am, noon and 6:00 pm.
  5. e Simulation of an 8-h dermal exposure to the NOEL of either malathion or chlorpyrifos starting 12 h prior to the onset of urine sampling.