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Table 4 Risk estimates based on comparisons of reconstructed absorbed dose of malathion and chlorpyrifos with WHO's ADI

From: Determination of no-observed effect level (NOEL)-biomarker equivalents to interpret biomonitoring data for organophosphorus pesticides in children

Scenario

Risk estimatea

No. of risk estimates >1

Metabolites considered

mean

SD

median

max

 

1- Comparison of the dose, reconstructed from creatinine-adjusted concentrations, with the ADI

     

Methylphosphates

1.10

2.18

0.51

29.1

130

Ethylphosphates

0.05

0.08

0.03

0.8

0

Sum of methyl + ethylphosphates

1.18

2.21

0.55

29.4

139

2- Comparison of the dose, reconstructed from volume-weighted concentrations, with the ADI

     

Methylphosphates

0.30

0.55

0.13

7.5

22

Ethylphosphates

0.07

0.13

0.04

1.6

2

Sum of methyl + ethylphosphates

0.36

0.61

0.19

7.8

33

  1. a The risk estimate corresponds to the ratio of calculated dose, reconstructed from methyl and ethyl phosphate urinary excretion, divided by WHO's ADI.