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Table 7 Optimal (integral) latency, LRT and ERR, including "city", by dose range

From: Reanalysis of cancer mortality in Japanese A-bomb survivors exposed to low doses of radiation: bootstrap and simulation methods

Dose range Site Φm LRT2p-con
at Φm
LRT2p-lin
at Φm
ERR1
at Φm
Latency Range ERR0.025
at Φm
Latency Range
0-20 Stom 11 13.02
p = 0.007
12.27
p = 0.003
0.38 (0.11, 0.70)
(0.16, 0.65)*
5-18
5-21*
9-21nl
0.34 (0.11, 0.63)
(0.14, 0.59)*
5-21
5-21*
5-500 Stom 8 9.03
p = 0.025
5.74
p = 0.07
0.29 (0.06, 0.60)
(0.09, 0.55)*
7-9
5-11*
  
0-20 Liver 37 28.41
p < 10-7
18.96
p < 10-4
1.26 (0.61, 2.14)
(0.69, 1.97)*
29-43
29-43*
29-41nl
0.68 (0.18, 1.25)
(0.24, 1.20)*
29-44
29-44*
5-500 Liver 37 14.47
p = 0.003
10.55
p = 0.005
0.74 (0.25, 1.43)
(0.32, 1.30)*
34-41
34-42*
34-41nl
  
0-20 Lung 16 10.43
p = 0.03
7.13
p = 0.05
1.00 (0.36, 1.84)
(0.42, 1.72)*
10-21
10-21*
12-16nl
0.80 (0.21, 1.66)
(0.28, 1.53)*
10-16
10-21*
5-500 Lung 16 21.69
p < 10-4
19.63
p < 10-5
1.33 (0.67, 2.22)
(0.73, 2.10)*
7-21
7-21*
12-21nl
  
0-20 Panc 10 14.89
p = 0.002
13.7
p < 0.001
11.32 (5.35, 16.46)
(5.44, 15.60)*
5-11
5-11*
7-11nl
10.77 (4.21, 16.05)
(4.70, 15.31)*
5-11
5-11*
5-500 Panc 42 1.97
p = 0.64
1.96
p = 0.38
0.44 (-, -) -   
0-20 Leuk 25 21.66
p < 10-4
21.66
p < 10-5
1.39 (0.09, 4.31)
(0.26, 3.79)*
24-25
24-26*
17-36nl
0.89 (0.11, 2.22)
(0.16, 2.16)*
19-33
17-33*
5-500 Leuk 28 14.76
p < 0.001
8.60
p = 0.013
1.83 (0.45, 3.92)
(0.59, 3.66)*
24-31
24-32*
24-28nl
  
  1. Dose range: data on which the two-phase model is fitted, including "city" as a control covariate
  2. Φm: latency, restricted to integers 5, 6,... 44, which maximises LRT2p-con subject to ERR1 ≥ 0
  3. LRT2p-con: Likelihood Ratio Test comparison of two-phase and control models at Φm. p values derived from Table 8
  4. LRT2p-lin: Likelihood Ratio Test comparison of two-phase and linear models at Φm. p values derived from Table 8
  5. ERR1: Excess Relative Risk at 10 mSv, from the two-phase model fitted across the dose range with latency Φm, and its BCa 95%CI (5000 replications)
  6. Latency range: integral latency range around Φm for which BCa 95%CI is strictly positive
  7. *: BCa 90%CIs (5000 replications)
  8. nl: integral latency range around Φm for which LRT2p-lin > 6
  9. ERR0.025: as above, for 0.25 mSv (computed only when Dose range = 0-20 mSv)