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Figure 4 | Environmental Health

Figure 4

From: Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study

Figure 4

B [ a ]P suppresses plasma cell differentiation under conditions of minimal proliferation. Purified B cells were activated for 4 days as described in Figure 1. B cells then were γ-irradiated (700 Rads) and re-cultured for an additional 4 days under plasma cell differentiation conditions. Cells were treated with vehicle or 10-6 M B [a]P during the first and/or second culture periods. A) Cells were phenotyped for CD20 and CD38 expression by flow cytometry. Dot plots obtained with cells from a representative donor (4 total) are shown. The percentages of CD20lo/CD38hi plasma cells are indicated in the upper left quadrants. B) Data from cells obtained from four donors and treated as in "A" are presented as mean percentage of CD20lo/CD38hi cells + SE. An asterisk (*) indicates a significant decrease relative to vehicle-treated cells (p < 0.05; Dunnett's).

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