Table 1 A profile of 37 human volunteer studies in the peer-reviewed literature
Authors | Study type* | Compound/Chemical Group | Route | Statistical Power | Details on Ethics Committee Approval | Higher Reference |
|---|---|---|---|---|---|---|
1. Bartels et al, 1998 [37] | A | Phenols | Dermal | n.a. | Yes | No |
2. Buchholz et al, 1999 [38] | A | Atrazine | Dermal | Weak | Yes | No |
3. Cnubben et al, 2002 [39] | Â | Phenols | Dermal and Intravenous | n.a. | Yes | No |
4. Dick et al, 1997 [46] | A | OC | Dermal | Acceptable | Yes | No |
5. DuBois and Mangun, 1947 [47] | T | OP | Oral | Weak | Not provided | No |
6. Edson et al, 1967 [48] | T | OP | Oral | Acceptable | Not provided | No |
7. Flannigan et al, 1985 [49] | T | Permethrin | Dermal | Acceptable | Yes | No |
8. Griffin et al, 1999 [50] | A | OP | Oral and Dermal | Weak | Yes | No |
9. Guthrie et al, 1976 [51] | A, O | OP | Field study | Weak | Not provided | No |
10. Hayes et al, 1964 [52] | A, T, E | OP | Dermal and Ingestion | n.a. | Not provided | No |
11. Kezic et, 1996 [53] | A | Dichloro-propene | Dermal | n.a. | Yes | No |
12. Krieger et al, 1993 [54] | A | Captan | Dermal | Weak | Not provided | No |
13. Meaklim et al, 2003 [55] | A, T | OP | Oral | Weak | Yes | Yes |
14. Meuling et al 2005 [56] | A | OP | Dermal | Weak | Yes | No |
15. Moeller et al, 1962 [57] | T | OP | Oral | Acceptable | Not provided | No |
16. Moody et al 1992 [58] | A, E, O | Phenoxy herbicides | Oral | Weak | Yes | No |
17. Moody et al, 1990 [59] | A | Phenoxy Herbicides | Dermal | Weak | Yes | No |
18. Nolan et al, 1984a [60] | A, T | OP | Oral and Dermal | Weak | Not provided | No |
19. Nolan et al, 1984b [61] | A | OP | Oral and Dermal | Acceptable | Yes | No |
20. Ramsey et al 1992 [45] | A | Fluazifop-butyl Herbicide | Dermal | Acceptable | Yes | No |
21. Rao et al, 1979 [62] | T | OP | Ingestion | Weak | Not provided | No |
22. Rider et al, 1975 [63] | T | OP | Oral | Acceptable | Not provided | Yes |
23. Roy et al, 2006 [40] | A, T, E | N,N-diethyl-m-toluamide and permethrin | Dermal | Weak | Yes | No |
24. Sanderson and Edson, 1964 [64] | T | OP | Oral | Weak | Not provided | No |
25. Sauerhoff et al, 1977 [65] | A | Phenoxy Herbicide | Oral | n.a. | Not provided | No |
26. Selim et al, 1999 [66] | A | 2,4-D | Oral | Weak | Not provided | Partly |
27. Selim et al, 1995 [67] | A | Piperonyl butoxide | Dermal | Weak | Yes | No |
28. Timchalk et al, 1998 [68] | A | Phenols | Dermal | Weak | Yes | No |
29. Verberk et al, 1977 [69] | T | OP | Oral | Acceptable | Not provided | No |
30. Verberk, 1977 [70] | T | OP | Oral | Acceptable | Not provided | No |
31. Vessell et al, 1975 [71] | A, E, O | Warfarin (rodenticide) | Oral | Acceptable | Not provided | No |
32. Wester et al, 1993 [72] | A | OP | Dermal | Acceptable | Not provided | No |
33. Wester et al, 1994 [73] | A | Pyrethrin and piperonyl butoxide | Dermal | Weak | Yes | No |
34. Wilks et al. 1993 [41] | A | Herbicide | Oral | Acceptable | Yes | No |
35. Williams et al, 2004 [44] | A | OP | Dermal | Acceptable | Yes | No |
36. Woollen et al, 1991 [43] | A | Fluazifop-butyl herbicide | Oral | Weak | Yes | No |
37. Woollen et al, 1992 [42] | A | Pyrethroid Insecticide | Oral and Dermal | Acceptable | Yes | No |