Neurodevelopmental toxicity of prenatal polychlorinated biphenyls (PCBs) by chemical structure and activity: a birth cohort study

Table 3 Estimated coefficients with p-values of PCBs and their subsets in relation to BISD at age of16 months, 2002-2004^†.

Log transformed	Maternal sera (N = 760)				Cord sera (N = 258)
Exposure Variables	MDI		PDI		MDI		PDI
	β	SE	β	SE	β	SE	β	SE
4 major PCBs^‡ (∑non-dioxin-like PCBs)	-0.39	0.62	-0.59	0.73	-1.02	0.94	-1.95*	1.13
∑ Dioxin-like mono-ortho PCBs ^‡	-1.60***	0.45	-1.26**	0.53	-1.40*	0.72	-1.99**	0.87
∑Anti-estrogenic PCBs^‡	-0.47	0.61	-0.58	0.72	-0.93	0.94	-1.85	1.13
PCB 118	-1.17***	0.39	-1.04**	0.46	-1.44**	0.64	-2.04***	0.77
PCB 138	-0.30	0.59	-0.53	0.70	-1.35	0.91	-2.27**	1.09
PCB 153	-0.33	0.62	-0.63	0.73	-1.22	0.94	-2.14*	1.14
PCB 156	-1.46***	0.43	-1.02**	0.50	-0.50	0.71	-0.63	0.86
PCB 170	-0.54	0.60	-0.58	0.71	-0.62	0.77	-1.90*	0.94
PCB 180	-0.36	0.61	-0.47	0.72	-0.55	0.94	-1.26	1.13

*P < 0.1; **P < 0.05; *** P < 0.01; Regression parameter coefficients represent score change in PDI and MDI for a one-unit change in log_e [exposure concentration ng/mg lipid].
^‡ ∑4 major PCBs (non-dioxin-like PCBs), sum of PCB #138, #153, #170 and #180; ∑ Dioxin-like mono-ortho PCBs, sum of PCB #118, and #156; ∑Anti-estrogenic PCBs, sum of PCB #138, #156, #170, and #180
^† After adjusting for district, HOME, sex, Raven score from multiple linear regression models.

ISSN: 1476-069X