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Table 4 Adjusted association between serum and meconium biomarkers of tobacco smoke exposure and infant birth weight.*

From: A prospective cohort study of biomarkers of prenatal tobacco smoke exposure: the correlation between serum and meconium and their association with infant birth weight

 

N

Mean Birth Weight

Change in Birth Weight

(95% CI)

Confidence Limit Difference†

Meconium NIC

    

   Unexposed (< LOD)

62

3386

Ref

---

   SHS (LOD - 10 ng/g)

212

3251

-136 (-295, 24)

320

   Active (> 10 ng/g)

28

3252

-135 (-395, 126)

520

   Continuous†

302

---

-62 (-178, 53)

231

Meconium COT

    

   Unexposed (< LOD)

97

3317

Ref

---

   SHS (LOD - 5 ng/g)

171

3286

-27 (-175, 120)

295

   Active (> 5 ng/g)

34

3207

-106 (-348, 135)

482

   Continuous†

302

---

-61 (-132, 10)

143

Meconium 3HC

    

   Unexposed (< LOD)

135

3335

Ref

---

   SHS (LOD - 10 ng/g)

139

3235

-100 (-246, 46)

292

   Active (> 10 ng/g)

28

3278

-57 (-307, 192)

500

   Continuous†

302

---

-30 (-96, 36)

132

Mean Serum COT

    

   Unexposed (< LOD)

122

3377

Reference

---

   SHS (LOD to 3 ng/mL)

148

3265

-112 (-264, 41)

305

   Active (> 3 ng/mL)

32

3188

-189 (-462, 84)

545

   Continuous†

302

---

-60 (-135, 16)

150

16 Week Serum COT

    

   Unexposed (< LOD)

101

3312

Reference

---

   SHS (LOD to 3 ng/mL)

162

3292

-20 (-173, 132)

305

   Active (> 3 ng/mL)

32

3203

-109 (-386, 168)

554

   Continuous†

295

---

-59 (-125, 7)

132

26 Week Serum COT

    

   Unexposed (< LOD)

126

3282

Reference

---

   SHS (LOD to 3 ng/mL)

138

3302

20 (-135, 175)

305

   Active (> 3 ng/mL)

29

3144

-138 (-425, 150)

554

   Continuous†

293

---

-41 (-104, 21)

125

Birth Serum COT

    

   Unexposed (< LOD)

121

3416

Reference

---

   SHS (LOD to 3 ng/mL)

131

3319

-97 (-248, 54)

302

   Active (> 3 ng/mL)

29

3226

-190 (-462, 82)

545

   Continuous†

281

---

-40 (-104, 24)

128

  1. *-Adjusted for maternal age (18 to <25, 25 to <35, and 35+ years), race (non-Hispanic white, non-Hispanic black, and other), education (< 12, 12, and >12 years), martial status (married and unmarried), depression (minimal, mild, and moderate/severe), parity (0, 1, and >1) and maternal weight.
  2. †-Calculated by subtracting the lower 95% confidence limit from the upper 95% confidence limit
  3. ‡-Coefficients represent change in birth weight for a 10-fold increase in metabolite concentration.