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Table 3 Comparison of concentrations with sensitising effects in human (HRIPT) or in mice (LLNA) to the estimated concentrations of application in products of daily use

From: Consumer exposure to biocides - identification of relevant sources and evaluation of possible health effects

Active substance Sensitising concentration in human (HRIPT) Sensitising concentration in animal testing (LLNA) Concentration of application
    Cleaning & washing Cosmetics Home improvement
CMI/MI 12.5 ppm [26](challenge conc. 12.5 ppm) 75 ppm (EC3) [27] ≤ 60 ppm 2.5 - 7.5 ppm (15 ppma)  
Glutardialdehyde 5% [28](challenge conc. 0.5%) 0.1% (EC3) [29] 0.01 - 0.5% ≤ 0.1% (0.1%a)  
Formaldehyde 1% [28](challenge conc. 1%) 0.35% (EC3) [30] ≤ 0.05% ≤ 0.2% (0.2%a) ≤ 0.1%
Bronopol 5% [28](challenge conc. 2.5%)   0.0011 - 0.035% 0.01 - 0.1% (0.1%a) 0.0011 - 0.035%
Chloroacetamide 0.5% [31](challenge conc. 0.5%)   0.1 - 0.3% ≤ 0.3% (0.3%a) 0.1 - 0.3%
  1. CMI/MI = mixture of 5-chloro-2-methyl-2H-isothiazolin-3-one and 2-methyl-2H-isothiazolin-3-oneHRIPT: Human Repeat Insult Patch test
  2. LLNA: Local lymph node assay
  3. EC3: concentration leading to a triplicate proliferation rate in the Local lymph node assay.
  4. a = max. value of cosmetics directive [17]
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Environmental Health

ISSN: 1476-069X