Effect modification of air pollution on Urinary 8-Hydroxy-2'-Deoxyguanosine by genotypes: an application of the multiple testing procedure to identify significant SNP interactions

Table 3 Statistical p-values for the interaction between pollutants and SNPs from MTP model using family-wise error rate and step-down max T method *

SNP	OC	SO₄ ^2-	O₃
CAT (C/T) rs480575	0.770	1.000	1.000
CAT(A/G) rs1001179	0.770	0.825	0.749
CAT(G/A) rs2284367	0.037	0.771	0.531
CAT (A/G) rs2300181	0.131	0.976	1.00
GC (C/A) rs2282679	0.025	1.000	0.999
GC (T/C) rs1155563	0.027	1.000	0.999
GCLC (C/T) rs17883901	0.896	1.000	0.999
GCLM (A/G) rs2301022	0.745	1.000	1.000
GCLM (A/G) rs3170633	0.368	0.995	1.000
HFE (G/T) rs1799945	0.997	0.995	1.000
HFE (G/A) rs1800562	0.417	1.000	1.000
HMOX (A/T) rs2071746	0.368	0.995	1.000
HMOX (C/G) rs2071747	0.177	0.732	0.999
HMOX (G/A) rs2071749	0.770	1.000	1.000
HMOX (C/G) rs5995098	0.177	1.000	1.000
GSTP1 (A/G) rs1695	0.997	0.995	1.000
GSTP1 (C/T) rs1799811	0.997	0.091	0.994
GSTT1	0.177	0.965	1.000
GSTM1	0.037	0.984	1.000
HMOX-1	0.758	1.000	1.000

* using 24-, 20- and 18-day moving averages of OC, SO₄ ^2- and maximal 1-hour O₃, respectively.

ISSN: 1476-069X