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Table 3 The percentage change (% Change) in antibody concentration at age 7 years when the PFAS concentration is doubled. Results are from multiple linear regressions for PFAS concentrations at age 7 years (6 models shown in row 1--2), structural equations models of latent individual PFAS measured by 5- and 7-year concentrations (6 models shown in row 3–4), and one structural equation model with all three latent PFASs (1 model shown in row 5–6). All models were adjusted for the covariates gender, age, and booster type

From: Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates

  

PFOS

PFOA

PFHxS

Antibody

N

% Change

95 % CI

% Change

95 % CI

% Change

95 % CI

Linear regression:

       

  Anti-diphtheria

443

−30.3

−47.3, −7.8

−25.4

−40.9, −5.8

−16.7

−30.8, 0.2

  Anti-tetanus

443

−9.1

−32.8, 23.0

−20.5

−38.2, 2.1

−22.3

−36.3, −5.2

SEMa (Additional file 1: Model 1)

       

  Anti-diphtheria

448

−34.3

−52.8, −8.9

−34.7

−52.5, −10.2

−13.9

−27.9, 2.7

  Anti-tetanus

448

−16.3

−41.5, 19.3

−38.2

−56.1, −13.0

−18.7

−32.8, −1.7

SEM mutually adjustedb, Additional file 1: Model 2

       

  Anti-diphtheria

448

−26.1

−49.4, 7.9

−26.9

−47.4, 1.5

1.7

−17.7, 25.8

  Anti-tetanus

448

18.7

−21.2, 78.7

−29.6

−50.6, 0.4

−15.0

−32.4, 6.8

  1. aSee Fig. 1. Goodness of fits: χ2-test P: 0.08–0.88, RMSEA: ≤ 0.01–0.06, CFI: 0.99–1.00, SRMR: 0.01–0.02
  2. bSee Additional file 1: Figure S2. Goodness of fits: χ2-test P: ≤ 0.01, RMSEA: 0.06, CFI: 0.99, SRMR: 0.03