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Table 4 Structural equation models for the association between antibodies and latent joint PFAS concentrations. Shown are models for latent PFAS at age 5 years (row 1), latent PFAS at age 7 years (row 2), and latent childhood PFAS (row 3). % Change indicates the percentages change in antibody concentration for a 2-fold PFAS concentration. All models were adjusted for the covariates gender, age, and booster type

From: Structural equation modeling of immunotoxicity associated with exposure to perfluorinated alkylates

  

Diphtheria

Tetanus

 

Joint

Model

N

% Change

95 % CI

% Change

95 % CI

P a

% Change

95 % CI

Additional file 1: Model 3

        

PFAS at age 5b

448

−44.8

−65.8, −11.0

−55.9

−73.6, −26.2

0.40

−50.0

−67.2, 23.8

PFAS at age 7c

448

−57.5

−77.1, −21.2

−49.8

−74.1, −2.8

0.64

−54.4

−73.3, −22.0

Additional file 1: Model 5d

        

PFAS childhood

448

−57.5

−76.9, −21.8

−60.1

−79.3, −22.8

0.64

−55.5

−73.4, −25.5

  1. aP-value for the test of same effect on the two antibodies
  2. bGoodness-of-fit (same effect model,): χ2-test P: 0.20, RMSEA: 0.03, CFI: 0.99, SRMR: 0.02
  3. cGoodness-of-fit (same effect model): χ2-test P: 0.41, RMSEA: 0.01, CFI: 0.99, SRMR: 0.02
  4. dGoodness-of-fit (same effect model): χ2-test P: 0.24, RMSEA: 0.02, CFI: 0.99, SRMR: 0.02