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Table 2 Analyses of temporal clustering of neuroblastic tumours at ages 0–24 years in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

  \( \widehat{\upbeta} \)b (SE)c
  one-sided P-value d
Type of analysis Within months Within quarters Within years Within full study period
Between fortnightse 0.846 (0.310) 0.501 (0.108) 0.201 (0.051) 0.168 (0.044)
  P = 0.004 P < 0.001 P < 0.001 P < 0.001
Between months   0.495 (0.165) 0.221 (0.073) 0.154 (0.062)
   P = 0.002 P = 0.002 P = 0.008
Between quarters    0.201 (0.140) 0.020 (0.107)
    P = 0.087 P = 0.39
Between years     −0.299 (0.216)
     P = 0.92
  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses