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Table 5 Analyses of temporal clustering of neuroblastic tumours at ages 0-24 years, separately for males and females in the NRYPMDRa

From: Temporal clustering of neuroblastic tumours in children and young adults from Northern England

   \( \widehat{\upbeta} \)b (SE)c
   one-sided P-value d
Type of analysis   Within months Within quarters Within years Within full study period
Between fortnightse Males 0.507 (0.423) 0.541 (0.162) 0.297 (0.063) 0.150 (0.044)
   P = 0.12 P = 0.002 P < 0.001 P = 0.002
  Females 2.095 (0.894) 0.157 (0.194) 0.036 (0.068) 0.005 (0.044)
   P = 0.004 P = 0.19 P = 0.29 P = 0.39
Between months Males   0.831 (0.248) 0.417 (0.089) 0.204 (0.062)
    P < 0.001 P < 0.001 P = 0.002
  Females   −0.160 (0.282) −0.027 (0.095) −0.058 (0.062)
    P = 0.69 P = 0.59 P = 0.78
Between quarters Males    0.508 (0.170) 0.134 (0.107)
     P = 0.003 P = 0.10
  Females    0.039 (0.181) −0.064 (0.107)
     P = 0.39 P = 0.68
Between years Males     −0.435 (0.217)
      P = 0.99
  Females     −0.185 (0.217)
      P = 0.79
  1. a)Based on cases diagnosed during 1968–2011 inclusive
  2. b)\( \widehat{\upbeta} \) is the one-step estimate of β, the extra-Poisson variation, calculated as S/i(0) in the notation of Muirhead [42]
  3. c)SE is the standard error of \( \widehat{\upbeta} \) in the absence of extra-Poisson variation, calculated as 1/√i(0) in the notation of Muirhead [42]
  4. d)P-values have been calculated using 10000 simulations, assuming Poisson variation. All P-values are one-sided
  5. e)Cases with a diagnosis date of the 15th of the month have been excluded from the analyses between fortnights but have been included in the other analyses