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Table 3 Associations between quartiles of maternal urinary BPA and phthalate concentrations and mean change in birth outcomes

From: Parental urinary biomarkers of preconception exposure to bisphenol A and phthalates in relation to birth outcomes

 

BW (g)

BL (cm)

HC (cm)

PI (g/cm3)

GA (days)

Chemical quartiles (ng/mL)

β (95 % CI)

β (95 % CI)

β (95 % CI)

β (95 % CI)

β (95 % CI)

Low molecular weight

mMP

     

1st (≤ -0.004)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (-0.001 - 0.33)

−177.6 (-344.9, -10.3)*

−1.6 (-2.6, -0.5)**

−0.3 (-1.1, 0.6)

0.1 (-0.1, 0.2)

−5.5 (-10.0, -1.0)*

3rd (0.34 - 1.68)

−168.9 (-375.7, 37.9)

−1.5 (-2.8, -0.1)*

−0.4 (-1.3, 0.6)

0.1 (0.0, 0.3)

−3.3 (-9.0, 2.5)

4th (≥1.69)

−94.0 (-280.5, 92.4)

−1.0 (-2.1, 0.1)

−0.2 (-1.1, 0.8)

0.1 (-0.1, 0.2)

−4.2 (-9.7, 1.4)

p-trend

0.94

0.33

0.70

0.34

0.45

mEP

     

1st (≤ 26.9)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (27.3 - 65.3)

−34.6 (-225.4, 156.2)

−0.1 (-1.1, 1.0)

−0.3 (-1.1, 0.5)

0.0 (-0.2, 0.2)

2.7 (-2.2, 7.5)

3rd (66.1 - 203)

−200.2 (-386.9, -13.4)*

−0.1 (-1.2, 0.9)

−1.4 (-2.3, -0.6)**

−0.1 (-0.3, 0.1)

−1.8 (-6.6, 2.9)

4th (≥ 203)

−72.1 (-287.5, 143.4)

−0.3 (-1.5, 0.9)

−0.6 (-1.6, 0.4)

0.0 (-0.2, 0.2)

0.6 (-4.9, 6.1)

p-trend

0.80

0.52

0.36

0.58

0.19

DEHP Metabolites

mEHP

     

1st (≤ -1.89)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (-1.88 - -0.000716)

63.0 (-150.4, 276.3)

0.2 (-1.0, 1.3)

0.4 (-0.5, 1.3)

0.0 (-0.1, 0.1)

1.4 (-3.8, 6.6)

3rd (0.0340 - 3.73)

139.0 (-84.4, 362.5)

0.4 (-0.6, 1.4)

0.4 (-0.1, 1.5)

0.1 (-0.1, 0.2)

5.7 (0.5, 10.8)*

4th (≥ 3.81)

138.5 (-70.7, 347.6)

0.4 (-0.8, 1.6)

−0.2 (-1.4, 1.0)

0.1 (-0.1, 0.2)

3.6 (-2.2, 9.5)

p-trend

0.09

0.37

0.81

0.20

0.10

mEOHP

     

1st (≤ 2.02)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (2.03 - 6.14)

−83.0 (-261.7, 95.8)

−0.6 (-1.7, 0.5)

−0.4 (-1.3, 0.5)

0.1 (-0.1, 0.2)

−0.3 (-5.2, 4.6)

3rd (6.15 - 15.6)

−162.4 (-350.4, 25.7)

−0.5 (-1.7, 0.8)

−1.3 (-2.2, -0.4)**

0.0 (-0.2, 0.1)

1.5 (-3.8, 6.7)

4th (≥ 15.8)

41.8 (-169.8, 253.5)

−0.1 (-1.3, 1.2)

−1.0 (-2.0, 0.1)

0.1 (-0.1, 0.2)

0.7 (-5.0, 6.4)

p-trend

0.43

0.93

0.18

0.21

0.56

mECPP

     

1st (≤ 5.70)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (5.71 - 14.96)

−154.4 (-331.2, 22.5)

−0.5 (-1.6, 0.5)

−0.9 (-1.8, -0.1)*

0.0 (-0.2, 0.2)

2.0 (-2.9, 6.9)

3rd (14.98 -36.3)

−13.4 (-200.3, 173.5)

−0.1 (-1.4, 1.2)

−0.8 (-1.7, 0.2)

0.0 (-0.2, 0.2)

1.1 (-4.5, 6.7)

4th (≥ 36.7)

39.7 (-178.7, 258.1)

0.2 (-1.2, 1.7)

−0.9 (-2.0, 0.2)

0.0 (-0.2, 0.2)

1.9 (-4.6, 8.4)

p-trend

0.40

0.74

0.20

0.53

0.47

mCMHP

     

1st (≤ 4.21)

Ref.

Ref.

Ref.

Ref.

 

2nd (4.22 - 11.3)

−201.7 (-372.7, -30.7)**

−1.1 (-2.2, 0.0)

−0.2 (-1.1, 0.7)

0.0 (-0.1, 0.1)

−1.4 (-6.8, 4.0)

3rd (11.4 - 30.0)

−70.0 (-256.6, 118.7)

−0.4 (-1.6, 0.8)

−0.2 (-1.2, 0.9)

0.0 (-0.1, 0.2)

2.1 (-4.9, 9.1)

4th (≥ 30.03)

44.2 (-196.7, 285.1)

−0.5 (-1.9, 1.0)

−0.8 (-2.0, 0.3)

0.1 (-0.1, 0.4)

1.3 (-6.2, 8.8)

p-trend

0.68

0.38

0.19

0.14

0.65

High Molecular Weight

mOP

     

1st (≤ -0.110)

Ref.

Ref.

Ref.

Ref.

Ref.

2nd (-0.111 - -0.0563)

−215.4 (-387.1, -43.7)**

−0.71 (-1.8, 0.4)

−0.11 (-1.1, 0.8)

0.0 (-0.2, 0.1)

5.2 (-9.9, -0.4)*

3rd (-0.0564 - 0.022)

−75.3 (-283.3, 132.6)

−0.3 (-1.4, 0.8)

−0.5 (-1.5, 0.5)

0.0 (-0.1, 0.2)

−2.5 (-7.7, 2.7)

4th (≥ 0.024)

−81.8 (-251.7, 88.0)

0.12 (-0.9, 1.1)

−0.74 (-1.7, 0.2)

−0.1 (-0.2, 0.1)

−4.9 (-10.0, 0.3)

p-trend

0.30

0.91

0.11

0.40

0.11

mNP

     

1st (≤ -0.079)

Ref.

Ref.

Ref.

Ref.

 

2nd (-0.0789 - -0.0006)

−87.4 (-258.8, 83.9)

−0.4 (-1.5, 0.6)

0.4 (-0.5, 1.3)

0.0 (-0.1, 0.2)

−2.9 (-7.5, 1.7)

3rd (-0.0005 - 0.067)

53.9 (-126.1, 233.9)

0.7 (-0.5, 1.8)

0.1 (-0.9, 1.0)

0.0 (-0.2, 0.1)

−4.0 (-9.0, 1.0)

4th (≥ 0.074)

−149.8 (-327.4, 27.8)

−0.1 (-1.2, 0.9)

−0.1 (-1.0, 0.8)

−0.1 (-0.2, 0.1)

−7.0 (-12.3, -1.6)**

p-trend

0.30

0.95

0.98

0.40

0.02

  1. NOTE: Significant findings are in boldface
  2. Abbreviations: BW birth weight (grams), BL birth length (centimeters), HC head circumference (centimeters), PI Ponderal Index (grams/centimeters3), GA gestational age (days), mMP monomethyl phthalate, mEP monoethyl phthalate, mEHP monoethylhexyl phthalate, mEOHP mono-(2-ethyl-5-oxohexyl) phthalate, mECPP mono-(5-carboxy-2-ethylpentyl) phthalate, mCMHP mono-[(2-carboxymethyl)hexyl] phthalate, mOP mono-n-octyl phthalate, mNP monoisononyl phthalate
  3. Models were adjusted for creatinine (ng/mL), age (years), race/ethnicity, BMI (kg/m2), education, cotinine (ng/mL), alcohol, conditional parity, infant gender, chemical*gender, paternal chemicals
  4. *p < 0.05 **p ≤ 0.01