Table 3 Adjusted difference in blood pressure (mmHg) at < 20 weeks of pregnancy, difference in highest blood pressure (mm Hg) at ≥ 20 weeks of pregnancy, and relative risk for pregnancy-induced hypertensive disease (gestational hypertension, preeclampsia, HELLP syndrome or eclampsia) according to terciles of creatinine-normalized urinary MBzP concentrations*

16 Week-1^st

6/122

3.9 (0.5, 6.5)

Ref

Ref

Ref

Ref

Ref

16 Week-2^nd

8/122

9.8 (6.5, 13)

0.5 (−1.1, 2.1)

−1.0 (−3.4, 1.5)

0.6 (−1.2, 2.4)

−0.3 (−3.0, 2.4)

1.44 (0.51, 4.02)

16 Week-3^rd

19/122

22 (13, 331)

2.2 (0.5, 3.9)

2.1 (−0.5, 4.7)

2.8 (0.9, 4.7)

2.3 (−0.3, 4.9)

2.92 (1.15, 7.41)

P-value for trend

<0.01

0.05

<0.01

0.05

0.01

26 Week-1^st

10/118

3.9 (0.1, 6.0)

Ref

Ref

Ref

26 Week-2^nd

7/119

9.0 (6.1, 14)

0.9 (−1.0, 2.9)

1.0 (−1.8, 3.8)

0.91 (0.35, 2.42)

26 Week-3^rd

15/118

23 (14, 178)

1.1 (−0.7, 3.0)

0.6 (−2.2, 3.4)

1.65 (0.76, 3.60)

P-value for trend

0.29

0.80

0.12

Pregnancy Average-1^st

8/123

4.5 (0.2, 6.4)

Ref

Ref

Ref

Pregnancy Average-2^nd

9/123

9.0 (6.4, 13)

1.0 (−0.8, 2.8)

1.1 (−1.5, 3.8)

1.30 (0.55, 3.09)

Pregnancy Average-3^rd

17/123

21 (13, 137)

2.1 (0.3, 3.9)

0.5 (−2.1, 3.1)

2.21 (0.96, 5.09)

P-value for trend

0.03

0.86

0.04