Associations of genetic variations in EYA4, GRHL2 and DFNA5 with noise-induced hearing loss in Chinese population: a case- control study

Table 3 Stratified analysis of associated SNPs by CNE and intensity of noise exposure

Exposure	SNP	Genotype	Control	Case	P1	P2	OR (95 % CI)
CNE
<95	rs2521758	TT	244	209	0.040		1
		GT/GG	12	3		0.042^a	0.115 (0.014, 0.921)^a
≥95		TT	205	232			1
		GT/GG	9	10		0.587^a	0.761 (0.284, 2.042)^a
Intensity (dB)
<88	rs212769	GG	211	181	0.041		1
		AG/AA	72	71		0.503^b	1.169 (0.740, 1.849)^b
≥88		GG	143	155			1
		AG/AA	45	66		0.046^b	1.727 (1.009, 2.954)^b

P1: P value of multiplicative interaction, which calculated by logistic model Multiplicative term; P2: P value of the association in each stratum
^acalculated with logistic regression adjusted by age, smoking, drinking
^bcalculated with logistic regression adjusted by age, smoking, drinking, years to noise exposure

ISSN: 1476-069X