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Table 6 Ordered logistic regression analysis of kidney function outcome measures against perfluoroalkyl acids

From: Association between perfluoroalkyl acids and kidney function in a cross-sectional study of adolescents

 

Odds Ratio for Higher Creatinine Quartile

Odds ratio for Lower eGFR Quartiles

Odds Ratio for Higher Uric Acid Quartiles

PFOA

   

 Quartile 1 (<2.5 ng/mL)

Reference

Reference

Reference

 Quartile 2 (2.5–3.5 ng/mL)

1.19 (0.91, 1.56)

1.16 (0.85, 1.59)

1.30 (0.89, 1,89)

 Quartile 3 (3.5–4.7 ng/mL

1.41 (0.95, 2.09)

1.54 (1.02, 2.33)*

1.24 (0.88, 1.74)

 Quartile 4 (≥4.7 ng/mL)

1.59 (1.13, 2.25)**

1.69 (1.19, 2.38)**

1.49 (1.08, 2.06)*

PFOS

   

 Quartile 1 (<7.9 ng/mL)

Reference

Reference

Reference

 Quartile 2 (7.9–12.8 ng/mL)

1.36 (0.93, 1.99)

1.37 (1.03, 1.82)*

1.15 (0.83, 1.58)

 Quartile 3 (12.8 19.4 ng/mL)

1.64 (1.12, 2.41)*

1.54 (1.09, 2.17)*

1.08 (0.78, 1.51)

 Quartile 4 (≥19.4 ng/mL)

1.70 (1.12, 2.59)*

1.96 (1.37, 2.86)***

1.46 (1.07, 2.01)*

PFNA

   

 Quartile 1 (<0.7 ng/mL)

Reference

Reference

Reference

 Quartile 2 (0.7–1.0 ng/mL)

1.11 (0.74, 1.66)

0.95 (0.671, 1.35)

1.16 (0.76, 1.79)

 Quartile 3 (1.0–1.5 ng/mL)

0.87 (0.62, 1.21)

0.78 (0.55, 1.11)

1.02 (0.70, 1.49)

 Quartile 4 (≥1.5 ng/mL)

1.28 (0.90, 1.81)

1.20 (0.85, 1.69)

1.39 (0.96, 2.01)

PFHxS

   

 Quartile 1 (<1 ng/mL)

Reference

Reference

Reference

 Quartile 2 (1–2 ng/mL)

0.99 (0.66, 1.48)

0.99 (0.66, 1.49)

1.09 (0.79, 1.50)

 Quartile 3 (2–3.95 ng/mL)

0.94 (0.64, 1.40)

0.88 (0.62, 1.25)

1.11 (0.77, 1.61)

 Quartile 4 (≥4 ng/mL)

0.91 (0.63, 1.33)

1.09 (0.77, 1.54)

0.95 (0.69, 1.31)

  1. All models control for Sex, poverty-income ratio, caregiver education, serum cotinine, prehypertension, insulin resistance, Body Mass Index, hypercholesterolemia and race/ethnicity categories. These ordered logistic regressions estimate one equation over all levels of the outcome variable and the coefficients shown per quartile of exposure represent the odds of being in the higher versus the lower quartiles of the outcome variable (or in the lower versus the higher quartiles in the case of eGFR)
  2. PFOA perfluorononanoic acid, PFOS perfluorooctane sulfonic acid, PFNA perfluorononanoic acid, PFHxS perfluorohexane sulfonic acid, eGFR estimated glomerular filtration rate
  3. * p < 0.05 ** p < 0.01 *** p < 0.001