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Table 2 Characteristics of participants by IL6 -572 G > C and IL6 -174 G > C genotypes

From: A common functional variant on the pro-inflammatory Interleukin-6 gene may modify the association between long-term PM10 exposure and diabetes

  IL6 -572 G > C IL6 -174 G > C
  GG (N = 3891) GC + CC (N = 519) P (Chi2) GG (N = 1618) GC (N = 2110) CC (N = 682) P (Chi2)
Proportion (%)
Females 48.4 49.1 0.768 48.3 48.1 50.6 0.509
Education ≥9 years 94.9 93.2 0.107 94.4 94.9 95.0 0.721
Never-smokers 44.3 45.6 0.490 42.4 44.8 48.1 0.036
Passive smoke exposure 46.4 46.6 0.927 48.6 45.4 44.4 0.078
Occupational VGDF exposure 42.8 42.4 0.845 43.9 42.6 40.9 0.398
Alcohol intake ≤1glass/day 91.0 91.4 0.620 89.8 91.2 93.0 0.050
Alcohol intake >1glass/day 9.0 9.6   10.2 8.8 7.0  
Portion of raw vegetables ≤3 days/week 18.2 20.8 0.150 17.4 19.1 19.4 0.351
Portion of raw vegetables >3 days/week 81.8 79.2   82.6 80.9 80.6  
Portion of fruits ≤3 days/week 35.8 35.6 0.923 35.0 36.2 36.7 0.657
Portion of fruits >3 days/week 64.2 64.4   65.0 63.8 63.3  
Portion of citrus fruits ≤3 days/week 64.2 64.0 0.909 64.2 63.9 64.8 0.917
Portion of citrus fruits >3 days/week 35.8 36.0   35.8 36.1 35.2  
Vigorous physical activity <0.5 h/week 35.5 37.2 0.449 37.3 34.6 34.2 0.082
Vigorous physical activity ≥0.5 h/week 64.5 62.8   62.1 65.4 65.8  
Diabetes cases 5.5 6.7 0.260 6.2 5.5 4.8 0.430
Areas: Basel 11.5 12.9 0.062 10.5 11.6 14.8 <0.001
 Wald 19.1 19.1   19.0 18.6 20.8  
 Davos 7.7 6.9   7.5 7.9 7.0  
 Lugano 12.6 14.6   15.0 12.6 8.4  
 Montana 11.1 6.9   9.2 11.2 12.0  
 Payerne 13.1 12.7   13.3 12.1 15.2  
 Aarau 16.6 19.3   16.9 17.6 14.4  
 Geneva 8.4 7.5   8.6 8.4 7.3  
Means (SD)    T-test     ANOVA
Age (years) 51.8 (11) 51.3 (11) 0.269 51.8 (11) 51.8 (11) 51.5 (11) 0.732
BMI (kg/m2) 25.8 (4.3) 26.3 (4.3) 0.025 26.0 (4.3) 25.8 (4.3) 25.9 (4.3) 0.152
Neighborhood SEI 63.7 (10) 63.8 (10) 0.827 63.5 (10) 63.9 (10) 63.8 (9) 0.455
10-year mean PM10 (μg/m3) 21.8 (7.3) 22.8 (7.2) 0.005 22.3 (7.4) 21.9 (7.3) 21.5 (6.9) 0.030
Pack-years of smokinga 0 (14) 0.1 (16) 0.296 0.3 (16) 0 (16) 0 (14) 0.524
  1. VGDF: vapours, gases, dusts and fumes; SD: standard deviation; BMI: body mass index; SEI: socio-economic index; PM10: particulate matter <10 μm in diameter. avalues represent median (interquartile range) and P-values represent significance level of median test