Maternal levels of endocrine disruptors, polybrominated diphenyl ethers, in early pregnancy are not associated with lower birth weight in the Canadian birth cohort GESTE

Table 4 Association between birth weight corrected for gestational age and maternal plasma levels of PBDEs (log₁₀) in early pregnancy

Log₁₀ PBDEs	Simple linear regressions^a		Multivariate linear regression^b
	Simple linear regressions^a		Model A		Model B
	β	95 % CI	β	95 % CI	β	95 % CI
Log₁₀ PBDEs (ng/g of lipid)
BDE-47	0.8	−93.1; 94.7	−25.1	−120.4; 70.3	−14.4	−129.9; 101.2
BDE-99	33.7	−34.8; 102.2	20.6	−49.1; 90.4	−1.6	−90.9; 87.7
BDE-100	25.4	−32.5; 83.3	23.9	−33.6; 81.5	4.7	−67.2; 76.5
BDE-153	−49.6	−100.9; 1.7	−40.7	−91.9; 10.6	−55.9	−118.9; 6.9
ΣPBDEs	−25.4	−128.7; 77.9	−46.1	−151.3; 59.1	−44.7	−173.6; 84.1
Log₁₀ PBDEs (ng/ml)^c
BDE-47	13.6	−82.7; 109.9	−16.1	−113.5; 81.3	3.0	−115.9; 121.9
BDE-99	46.7	−27.1; 120.5	30.1	−45.2; 105.4	10.2	−86.7; 107.1
BDE-100	30.7	−27.8; 89.2	27.9	−30.1; 85.9	11.6	−61.0; 84.2
BDE-153	−49.7	−103.1; 3.7	−39.6	−103.0; 23.8	−55.0	−120.6; 10.6
ΣPBDEs	−12.3	−123.2; 98.5	−39.2	−151.7; 73.3	−27.0	−166.1; 112.0
Log₁₀ PBDEs (ng/ml) adjusted for total plasma lipids.
BDE-47	14.5	−81.8; 110.8	−16.2	−113.6; 81.2	6.5	−112.3; 125.4
BDE-99	70.4	−8.6; 149.4	48.4	−32.3; 129.2	42.1	−63.7; 147.9
BDE-100	31.1	−27.4; 89.6	27.9	−30.1; 85.8	12.8	−59.7; 85.4
BDE-153	−45.4	−100.4; 9.6	−37.5	−92.2; 17.2	−47.1	−115.3; 21.1
ΣPBDEs	−2.6	−114.9; 109.7	−32.8	−146.5; 80.9	−9.3	−151.3; 132.6

Abbreviations: CI confidence interval, PBDE(s) Polybrominated diphenyl ether(s), ΣPBDE sum of BDE-47, 99, 100 and 153
^aNon-adjusted for potential confounders
^bAdjusted for potential confounders
Model A: Adjusted on mother’s age at delivery, marital status, BMI at recruitment, infection, smoking status during pregnancy, ΣPCBs (CB-138, CB-153 and CB-180 expressed in ng/g of lipid), mothers total blood levels of lead (ng/ml)
Model B: Model A + previous pregnancies history (preterm infant and low birth weight infant) in multipara only (N = 234)
^cTotal lipids were not taken into account in these models

ISSN: 1476-069X