Maternal body burdens of PCDD/Fs and PBDEs are associated with maternal serum levels of thyroid hormones in early pregnancy: a cross-sectional study

Table 3 Regression coefficients (β, mean ± standard error) for associations between maternal body burdens of PCB, PCDD/F and PBDE and first trimester thyroid hormone concentrations and third trimester thyroid peroxidase antibody (a-TPO) concentrations

Body burdens^a	N	Total T3	Free T4	TSH	a-TPO^b
Unadjusted model
di-ortho PCB	219	−0.15 ± 0.06*	0.04 ± 0.25	0.08 ± 0.15	0.013 ± 0.063
mono-ortho PCB TEQ	219	−0.15 ± 0.06*	0.16 ± 0.22	0.07 ± 0.14	−0.0096 ± 0.055
PCDD/F TEQ	67	−0.55 ± 0.14*	0.10 ± 0.67	0.45 ± 0.38	0.0055 ± 0.17
tetra-pentaPBDE	127	0.009 ± 0.06	0.35 ± 0.26	0.05 ± 0.16	0.035 ± 0.051
BDE-153	127	−0.25 ± 0.07*	0.01 ± 0.34	0.15 ± 0.20	0.072 ± 0.068
Multivariate model ^c
di-ortho PCB	218	−0.07 ± 0.09	−0.19 ± 0.34	0.08 ± 0.21	−0.28 ± 0.089
mono-ortho PCB TEQ	218	−0.10 ± 0.07	0.09 ± 0.27	0.003 ± 0.17	−0.029 ± 0.065
PCDD/F TEQ	66	−0.54 ± 0.21*	−0.43 ± 0.89	−0.01 ± 0.53	−0.18 ± 0.25
tetra-pentaPBDE	126	0.02 ± 0.06	−0.01 ± 0.21	0.14 ± 0.12	0.048 ± 0.052
BDE-153	126	−0.20 ± 0.08*	−0.34 ± 0.37	0.17 ± 0.22	0.085 ± 0.076

^aLn-transformed blood serum concentrations in late pregnancy; di-ortho PCB (sum of PCB 138, 153 and 180) and mono-ortho PCB TEQ (sum of TEQs for PCB 105, 118, 156 and 167) [32]. Ln-transformed mother’s milk concentrations of PCDD/F TEQ (sum of TEQs for the 17 congeners with WHO TEFs) [32], tetra-pentaPBDE (sum of BDE-47, BDE-99, BDE-100) and BDE-153
^ba-TPO data were ln-transformed in the statistical analyses due to a log-normal distribution
^cAssociations adjusted for maternal age, pre-pregnancy BMI, smoking during pregnancy and season of sampling, *p ≤ 0.05

ISSN: 1476-069X