Skip to main content

Table 3 Regression coefficients (β, mean ± standard error) for associations between maternal body burdens of PCB, PCDD/F and PBDE and first trimester thyroid hormone concentrations and third trimester thyroid peroxidase antibody (a-TPO) concentrations

From: Maternal body burdens of PCDD/Fs and PBDEs are associated with maternal serum levels of thyroid hormones in early pregnancy: a cross-sectional study

Body burdensa N Total T3 Free T4 TSH a-TPOb
Unadjusted model      
di-ortho PCB 219 −0.15 ± 0.06* 0.04 ± 0.25 0.08 ± 0.15 0.013 ± 0.063
mono-ortho PCB TEQ 219 −0.15 ± 0.06* 0.16 ± 0.22 0.07 ± 0.14 −0.0096 ± 0.055
PCDD/F TEQ 67 −0.55 ± 0.14* 0.10 ± 0.67 0.45 ± 0.38 0.0055 ± 0.17
tetra-pentaPBDE 127 0.009 ± 0.06 0.35 ± 0.26 0.05 ± 0.16 0.035 ± 0.051
BDE-153 127 −0.25 ± 0.07* 0.01 ± 0.34 0.15 ± 0.20 0.072 ± 0.068
Multivariate model c      
di-ortho PCB 218 −0.07 ± 0.09 −0.19 ± 0.34 0.08 ± 0.21 −0.28 ± 0.089
mono-ortho PCB TEQ 218 −0.10 ± 0.07 0.09 ± 0.27 0.003 ± 0.17 −0.029 ± 0.065
PCDD/F TEQ 66 −0.54 ± 0.21* −0.43 ± 0.89 −0.01 ± 0.53 −0.18 ± 0.25
tetra-pentaPBDE 126 0.02 ± 0.06 −0.01 ± 0.21 0.14 ± 0.12 0.048 ± 0.052
BDE-153 126 −0.20 ± 0.08* −0.34 ± 0.37 0.17 ± 0.22 0.085 ± 0.076
  1. aLn-transformed blood serum concentrations in late pregnancy; di-ortho PCB (sum of PCB 138, 153 and 180) and mono-ortho PCB TEQ (sum of TEQs for PCB 105, 118, 156 and 167) [32]. Ln-transformed mother’s milk concentrations of PCDD/F TEQ (sum of TEQs for the 17 congeners with WHO TEFs) [32], tetra-pentaPBDE (sum of BDE-47, BDE-99, BDE-100) and BDE-153
  2. ba-TPO data were ln-transformed in the statistical analyses due to a log-normal distribution
  3. cAssociations adjusted for maternal age, pre-pregnancy BMI, smoking during pregnancy and season of sampling, *p ≤ 0.05