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Table 1 Key elements of a systematic review protocol

From: A proposed framework for the systematic review and integrated assessment (SYRINA) of endocrine disrupting chemicals

A well-defined study question
A reproducible, transparent literature-search strategy
Pre-determined method(s) used to screen studies based on inclusion/exclusion criteria
A method for evaluation of internal validity of included studies
A summarization of findings from included studies
A method for rating the quality of the evidence across studies
Procedures to synthesize data within individual evidence streams, including decision criteria, using standard terms
Methods to integrate multiple streams of evidence and reach uniform classifications based on objective criteria