Skip to main content

Table 3 BMD10 for liver carcinomas in female mice (from NCI, 1976)

From: Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures

Model Total number of parameters in the model AIC Goodness of fit test P-value Scaled residual near BMR BMD10
(mg/kg/d)
BMD10-HED (mg/kg/d)
Gamma-Restricted 3 147.182 0.014 0 0.671 0.1005
Gamma 3 141.305 0.568 0 2E-35 na
Logistic 2 166.361 0.000 3.47 1.824 0.2734
LogLogistic-Restricted 3 143.927 0.081 0 0.464 0.0695
LogLogistic 3 139.233 0.881 0 computation failed
LogProbit-Restricted 3 149.575 0.004 0 1.149 0.1722
LogProbit 3 139.233 0.881 0 computation failed
Multistage-Restricted 2 147.182 0.014 0 0.671 0.1005
Multistage 2 140.979 1.000 0 0.275 0.0412
Multistage-Cancer 1 2 147.182 0.014 0 0.671 0.1005
Multistage-Cancer 2 3 147.182 0.014 0 0.671 0.1005
Multistage-Cancer 3 4 147.182 0.014 0 0.671 0.1005
Probit 2 164.975 0.000 3.509 1.704 0.2553
Weibull-Restricted 3 147.182 0.014 0 0.671 0.1005
Weibull 3 147.182 0.014 0 0.671 0.1005
Quantal-Linear 3 147.182 0.014 0 0.671 0.1005
Minimal BMD na
Maximal BMD na
Ratio max/min na
BMD from best AIC model 0.0412
Geometric mean of BMDs for acceptable models na
  1. The benchmark response is 10 %. AIC: Akaïke’s Information Criterion. BMD10: Benchmark dose for 10 % excess risk. Results in bold are acceptable models according to these criteria: total number of parameters does not exceed the number of groups modeled (n = 3); and p-value > 0.1; and scaled residual < │2│ and no computation error or unrealistic graphical BMD10. If ratio max/min is less than 3, then geometric mean of acceptable models is selected, else the best AIC model is selected. “na”: not applicable