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Table 4 BMD10 for liver carcinomas in male mice (data from NCI, 1976)

From: Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures

Model Total number of parameters in the model AIC Goodness of fit test P-value Scaled residual near BMR BMD10 (mg/kg/d) BMD10-HED (mg/kg/d)
Gamma-Restricted 3 157.911 NA 0 0.841 0.1279
Gamma 3 157.911 NA 0 0.841 0.1279
Logistic 2 155.911 0.9773 0.002 0.545 0.0828
LogLogistic-Restricted 3 157.911 NA 0 1.136 0.1725
LogLogistic 3 157.911 NA 0 1.136 0.1725
LogProbit-Restricted 3 157.911 NA 0 1.078 0.1638
LogProbit 3 157.911 NA 0 1.078 0.1638
Multistage-Restricted 2 157.911 NA 0 0.536 0.0814
Multistage 2 157.911 NA 0 0.536 0.0814
Multistage-Cancer 1 2 156.027 0.733 0.007 0.257 0.0391
Multistage-Cancer 2 3 157.911 NA 0 0.536 0.0814
Multistage-Cancer 3 4 159.911 NA 0 0.373 0.0567
Probit 2 155.914 0.9557 −0.005 0.535 0.0812
Weibull-Restricted 3 157.911 NA 0 0.674 0.1024
Weibull 3 157.911 NA 0 0.674 0.1024
Quantal-Linear 3 156.027 0.733 0.007 0.257 0.0391
Minimal BMD 0.0391
Maximal BMD 0.0828
Ratio max/min 2.1
BMD from best AIC model 0.083
Geometric mean of acceptable models BMD 0.057
  1. The benchmark response is 10 %. AIC: Akaïke’s Information Criterion. BMD10: Benchmark dose for 10 % excess risk. Results in bold are acceptable models according to these criteria: total number of parameters does not exceed the number of groups modeled (n = 3); and p-value > 0.1; and scaled residual < │2│ and no computation error or unrealistic graphical BMD10. If ratio max/min is less than 3, then geometric mean of acceptable models is selected, else best AIC model is selected. “NA”: not applicable