|
Model
|
Total number of parameters in the model
|
AIC
|
Goodness of fit test P-value
|
Scaled residual near BMR
|
BMD10 (mg/kg/d)
|
BMD10-HED (mg/kg/d)
|
|---|
|
Gamma-Restricted
|
3
|
157.911
|
NA
|
0
|
0.841
|
0.1279
|
|
Gamma
|
3
|
157.911
|
NA
|
0
|
0.841
|
0.1279
|
|
Logistic
|
2
|
155.911
|
0.9773
|
0.002
|
0.545
|
0.0828
|
|
LogLogistic-Restricted
|
3
|
157.911
|
NA
|
0
|
1.136
|
0.1725
|
|
LogLogistic
|
3
|
157.911
|
NA
|
0
|
1.136
|
0.1725
|
|
LogProbit-Restricted
|
3
|
157.911
|
NA
|
0
|
1.078
|
0.1638
|
|
LogProbit
|
3
|
157.911
|
NA
|
0
|
1.078
|
0.1638
|
|
Multistage-Restricted
|
2
|
157.911
|
NA
|
0
|
0.536
|
0.0814
|
|
Multistage
|
2
|
157.911
|
NA
|
0
|
0.536
|
0.0814
|
|
Multistage-Cancer 1
|
2
|
156.027
|
0.733
|
0.007
|
0.257
|
0.0391
|
|
Multistage-Cancer 2
|
3
|
157.911
|
NA
|
0
|
0.536
|
0.0814
|
|
Multistage-Cancer 3
|
4
|
159.911
|
NA
|
0
|
0.373
|
0.0567
|
|
Probit
|
2
|
155.914
|
0.9557
|
−0.005
|
0.535
|
0.0812
|
|
Weibull-Restricted
|
3
|
157.911
|
NA
|
0
|
0.674
|
0.1024
|
|
Weibull
|
3
|
157.911
|
NA
|
0
|
0.674
|
0.1024
|
|
Quantal-Linear
|
3
|
156.027
|
0.733
|
0.007
|
0.257
|
0.0391
|
|
Minimal BMD
|
0.0391
|
|
Maximal BMD
|
0.0828
|
|
Ratio max/min
|
2.1
|
|
BMD from best AIC model
|
0.083
|
|
Geometric mean of acceptable models BMD
|
0.057
|
- The benchmark response is 10 %. AIC: Akaïke’s Information Criterion. BMD10: Benchmark dose for 10 % excess risk. Results in bold are acceptable models according to these criteria: total number of parameters does not exceed the number of groups modeled (n = 3); and p-value > 0.1; and scaled residual < │2│ and no computation error or unrealistic graphical BMD10. If ratio max/min is less than 3, then geometric mean of acceptable models is selected, else best AIC model is selected. “NA”: not applicable
