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Table 5 BMD10 for glomerulosclerosis in female rat (data from Larson, 1979, dose group 1 excluded)

From: Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures

Model

Total number of parameters in the model

AIC

Goodness of fit test P-value

Scaled residual near BMR

BMD10 (mg/kg/d)

BMD10-HED (mg/kg/d)

Gamma-Restricted

3

73.996

0.218

−0.25

0.0857

0.0219

Gamma

3

74.198

0.594

0.01

0.0043

0.0011

Logistic

2

78.734

0.009

1.19

0.2102

0.0537

LogLogistic-Restricted

3

72.206

0.848

−0.02

0.0495

0.0126

LogLogistic

3

74.083

0.679

0.01

0.0259

0.0066

LogProbit-Restricted

3

73.859

0.215

−0.15

0.1235

0.0315

LogProbit

3

74.093

0.671

0.01

0.0288

0.0073

Multistage-Restricted

2

73.996

0.218

−0.25

0.0857

0.0219

Multistage

2

73.915

0.969

0.00

0.0552

0.0141

Multistage-Cancer 1

2

73.996

0.218

−0.25

0.0857

0.0219

Multistage-Cancer 2

3

73.996

0.218

−0.25

0.0857

0.0219

Multistage-Cancer 3

4

73.996

0.218

−0.25

0.0857

0.0219

Probit

2

79.168

0.016

1.28

0.2378

0.0607

Weibull-Restricted

3

73.996

0.218

−0.25

0.0857

0.0219

Weibull

3

73.996

0.218

−0.25

0.0857

0.0219

Quantal-Linear

3

73.996

0.218

−0.25

0.0857

0.0219

Minimal BMD

0.001

Maximal BMD

0.032

Ratio max/min

29

BMD from best AIC model

0.0126

Geometric mean of acceptable models BMD

Not applicable

  1. The benchmark response is 10 %. AIC: Akaïke’s Information Criterion. BMD10: Benchmark dose for 10 % excess risk. Results in bold are acceptable models according to these criteria: total number of parameters does not exceed the number of groups modeled (n = 4); and p-value > 0.1; and scaled residual < │2│ and no computation error or unrealistic graphical BMD10. If ratio max/min is less than 3, then geometric mean of acceptable models is selected, else best AIC model is selected. “na”: not applicable