Public health and chronic low chlordecone exposure in Guadeloupe, Part 1: hazards, exposure-response functions, and exposures

Table 6 Blood chlordecone concentrations: averages by exposure group for purpose of risk assessment

Study name (time period)	Population	Group 1 (μg/L)	Group 2 (μg/L)	Group 3 (μg/L)	Group 4 (μg/L)	Group 5 (μg/L)	Weighted mean
INSERM (1999–2001)	Men 20-45y	1.06	1.56	3.90	7.25	14.79	7.14
KARUPROSTATE (2005–2006)	Men >44y	0.17	0.22	0.40	0.90	7.60	2.32
Difference : after 2003 - before 2003		−0.90	−1.34	−3.50	−6.35	−7.19	−4.82
HIBISCUS (2003)	Mother 17-45y	0.32	0.62	1.70	3.05	8.05	3.43
TIMOUN (2004–2007)	Mother 17-45y	0.18	nc	0.29	0.65	4.17	1.37
Difference : after 2003 - before 2003		−0.15	−0.40	−1.30	−2.15	−0.45	−1.11
HIBISCUS (2003)	Newborn	0.39	nc	0.55	0.95	2.11	1.00
TIMOUN (2004–2007)	Newborn	0.19	nc	nc	0.24	2.62	0.81
Difference : after 2003 - before 2003		−0.21			−0.71	+0.51	−019

Group 1 = βM value. βM is calculated with the β-substitution method from Ganser and Hewett 2010 [37]. Group 2 = geometric mean βM-P25. Group3 = arithmetic mean P25-P50. Group 4 = arithmetic mean P50-P75. Group 5 = geometric mean P75-Max. When a percentile value is censured by the limit of detection (example: P25 in Hibiscus newborn), means are not calculated. Then, for the next group the mean is calculated with βM and percentile value. Weighted means are the sum of group values weighted by the proportion of population in each group. Group 1 + group 2 = 25 %, group 3 = 25 %, group 4 = 25 % group 5 = 25 %. For TIMOUN new-born group 1 + 2 + 3 = 50 %, group 4 = 25 % and group 5 = 25 %

ISSN: 1476-069X