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Table 3 The association between extracellular miRNA expression and recent exposure to fine (PM2.5) and ultrafine (UFP) particles

From: Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva

  

miR-222

miR-146a

Pollution indicator

IQR

Effect size

95 % CI

p-value

Effect size

95 % CI

p-value

Indoor at school during the examination

UFP, #/cm3

8504

23.5

3.5–41.1

0.021

4.2

–9.4–17.8

0.54

PM2.5, μg/m3

2.8

4.7

−9.1–19.3

0.50

4.9

–4.6–14.8

0.31

Outdoor at school during the examination

UFP, #/cm3

28776

29.9

10.6–49.1

0.0027

10.6

n/a

0.13

PM2.5, μg/m3

10.33

–2.3

11.5–7.1

0.63

–1.4

–7.4–4.6

0.65

Modelled daily residential PM 2.5

Day of the examination (lag 0), μg/m3

15.3

8.20

–5.8–22.4

0.26

–1.6

–11.6–8.5

0.76

Day before the examination (lag 1), μg/m3

16.8

6.92

–6.8–20.8

0.33

–4.9

–15–5.1

0.34

Two days before the examination (lag 2), μg/m3

11.7

3.96

–5.4–13.4

0.41

–2.4

–9.2–4.4

0.48

Average of 48h before the examination, μg/m3

12.9

5.31

–5.7–16.4

0.35

–3.5

–11.5–4.5

0.39

  1. Estimated effects sizes are adjusted for school, time of the day, day of the week, age (continuous), gender, BMI (continuous), passive smoking, maternal education level, the hours TV/week and RNA content of the extracellular fraction. All estimates are represented as the % change in miRNA expression for an IQR increase in exposure to the pollutant
  2. P < 0.05 was considered as a significant association