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Table 3 The association between extracellular miRNA expression and recent exposure to fine (PM2.5) and ultrafine (UFP) particles

From: Recent exposure to ultrafine particles in school children alters miR-222 expression in the extracellular fraction of saliva

   miR-222 miR-146a
Pollution indicator IQR Effect size 95 % CI p-value Effect size 95 % CI p-value
Indoor at school during the examination
UFP, #/cm3 8504 23.5 3.5–41.1 0.021 4.2 –9.4–17.8 0.54
PM2.5, μg/m3 2.8 4.7 −9.1–19.3 0.50 4.9 –4.6–14.8 0.31
Outdoor at school during the examination
UFP, #/cm3 28776 29.9 10.6–49.1 0.0027 10.6 n/a 0.13
PM2.5, μg/m3 10.33 –2.3 11.5–7.1 0.63 –1.4 –7.4–4.6 0.65
Modelled daily residential PM 2.5
Day of the examination (lag 0), μg/m3 15.3 8.20 –5.8–22.4 0.26 –1.6 –11.6–8.5 0.76
Day before the examination (lag 1), μg/m3 16.8 6.92 –6.8–20.8 0.33 –4.9 –15–5.1 0.34
Two days before the examination (lag 2), μg/m3 11.7 3.96 –5.4–13.4 0.41 –2.4 –9.2–4.4 0.48
Average of 48h before the examination, μg/m3 12.9 5.31 –5.7–16.4 0.35 –3.5 –11.5–4.5 0.39
  1. Estimated effects sizes are adjusted for school, time of the day, day of the week, age (continuous), gender, BMI (continuous), passive smoking, maternal education level, the hours TV/week and RNA content of the extracellular fraction. All estimates are represented as the % change in miRNA expression for an IQR increase in exposure to the pollutant
  2. P < 0.05 was considered as a significant association