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Table 2 eMS with PM2.5-associated methylation and association between corresponding transcript gene expression with PM2.5, ranked by gene expression association with PM2.5

From: Long-term outdoor air pollution and DNA methylation in circulating monocytes: results from the Multi-Ethnic Study of Atherosclerosis (MESA)

   DNA Methylation Gene Expression
Genea Chr CpG β (95% CI) P-value Adjusted P-value Illumina Transcript β (95% CI) P-value Adjusted P-value
PM2.5
ANKHD1 5 cg20455854 0.139 (0.074, 0.203) 2.77 × 10−5 0.034 ILMN_1765091 −0.048 (−0.074, −0.022) 3.71 × 10−4 0.002
LGALS2 22 cg07855639 0.081 (0.043, 0.120) 3.28 × 10−5 0.034 ILMN_1687306 −0.147 (−0.240, −0.053) 0.002 0.005
ANKRD11 16 cg07598385 0.108 (0.056, 0.160) 4.97 × 10−5 0.034 ILMN_2108709 −0.075 (−0.142, −0.008) 0.028 0.046
BAZ2B 2 cg17360854 0.081 (0.042, 0.120) 5.08 × 10−5 0.034 ILMN_1720850 −0.016 (−0.060, 0.027) 0.463 0.578
PPIE 1 cg23599683 −0.057 (−0.085, −0.029) 7.17 × 10−5 0.039 ILMN_1680341 0.004 (−0.020, 0.028) 0.728 0.728
  1. PM2.5, fine particulate matter (per 2.5 μg/m3); chr chromosome, CI confidence interval
  2. a Gene corresponding to Illumina transcript associated with CpG methylation