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Table 3 Association between NHL and quartiles of measured body burden of six PCB congeners, specified PCB functional groups, HCB and DDE

From: Prediagnostic plasma concentrations of organochlorines and risk of B-cell non-Hodgkin lymphoma in envirogenomarkers: a nested case-control study

Exposure

Quartile

n. Ca

n. Co

OR

95% CI

P-value

p for trend

OR(adj)

95% CI

P-value

p for trend

PCB118

Q1 (8.46, 94.05)

80

68

1

   

1

   

Q2 (94.25, 148.04)

68

67

0.76

(0.44,1.32)

0.332

 

0.57

(0.31,1.08)

0.084

 

Q3 (148.37, 219.85)

42

66

0.45

(0.24,0.84)

0.012*

 

0.35

(0.17,0.72)

0.004*

 

Q4 (219.91, 901.63)

80

67

0.96

(0.49,1.87)

0.909

0.571

0.67

(0.3,1.49)

0.332

0.168

PCB138

Q1 (10.97, 396.03)

86

67

1

   

1

   

Q2 (399.73, 562.09)

60

67

0.67

(0.41,1.08)

0.102

 

0.53

(0.31,0.91)

0.021*

 

Q3 (562.64, 778.15)

63

67

0.63

(0.37,1.1)

0.104

 

0.50

(0.27,0.94)

0.031*

 

Q4 (778.44, 2675.35)

61

67

0.60

(0.33,1.08)

0.089

0.093

0.38

(0.18,0.78)

0.009*

0.010*

PCB153

Q1 (32.47, 812.10)

88

68

1

   

1

   

Q2 (813.60, 1083.97)

59

66

0.60

(0.36,1.03)

0.064

 

0.56

(0.31,1.02)

0.058

 

Q3 (1088.49, 1489.97)

60

67

0.54

(0.3,0.98)

0.044*

 

0.47

(0.24,0.93)

0.031*

 

Q4 (1493.70, 4334.12)

63

67

0.55

(0.3,1.04)

0.066

0.078

0.37

(0.17,0.78)

0.009*

0.011*

PCB156

Q1 (15.50, 69.69.62)

75

67

1

   

1

   

Q2 (69.95, 95.44)

71

67

0.88

(0.49,1.56)

0.654

 

0.9

(0.48,1.71)

0.754

 

Q3 (95.76, 126.68)

51

67

0.59

(0.31,1.11)

0.100

 

0.56

(0.27,1.16)

0.118

 

Q4 (126.87, 394.89)

73

67

0.86

(0.45,1.64)

0.644

0.545

0.69

(0.33,1.45)

0.326

0.228

PCB170

Q1 (50.39, 257.50)

73

67

1

   

1

   

Q2 (257.62, 358.81)

82

68

0.99

(0.59,1.66)

0.967

 

0.9

(0.51,1.6)

0.718

 

Q3 (359.10, 468.52)

43

66

0.48

(0.25,0.92)

0.028*

 

0.37

(0.17,0.79)

0.010*

 

Q4 (468.55, 1291.23)

72

67

0.83

(0.45,1.53)

0.55

0.356

0.59

(0.28,1.23)

0.160

0.091

PCB180

Q1 (100.08, 533.51)

72

67

1

   

1

   

Q2 (533.84, 730.03)

78

68

1.03

(0.61,1.73)

0.926

 

1

(0.55,1.81)

0.999

 

Q3 (730.81, 966.02)

46

66

0.57

(0.31,1.05)

0.071

 

0.45

(0.21,0.95)

0.035*

 

Q4 (966.55, 2708,83)

74

67

0.94

(0.52,1.69)

0.827

0.595

0.68

(0.32,1.42)

0.300

0.168

HCB

Q1 (62.47, 181.87)

85

67

1

   

1

   

Q2 (184.78, 288.81)

62

67

0.58

(0.32,1.03)

0.064

 

0.52

(0.27,1.02)

0.057

 

Q3 (289.49, 474.86)

59

67

0.47

(0.24,0.94)

0.032*

 

0.28

(0.12,0.65)

0.003*

 

Q4 (477.00, 3882.19)

64

66

0.49

(0.22,1.07)

0.074

0.061

0.35

(0.14,0.87)

0.023*

0.014*

DDE

Q1 (16.40, 1308.26)

81

67

1

   

1

   

Q2 (1310.23, 2666.60)

62

67

0.65

(0.37,1.14)

0.137

 

0.55

(0.28,1.05)

0.07

 

Q3 (2675.27, 5523.58)

68

68

0.67

(0.37,1.21)

0.186

 

0.40

(0.20,0.84)

0.015*

 

Q4 (5528.29, 30992.76)

59

66

0.55

(0.28,1.08)

0.082

0.106

0.34

(0.15,0.77)

0.010*

0.008*

  1. OR – conditional logistic regression accounting for matching factors
  2. OR(adj) – conditional logistic regression additionally adjusting for BMI, height, educational level, vegetables, dairy, protein, total fat, alcohol
  3. *Significant at the 95% confidence level