Exome-wide association study identifies genetic polymorphisms of C12orf51, MYL2, and ALDH2 associated with blood lead levels in the general Korean population

Table 2 The 12 single nucleotide polymorphisms associated with blood lead levels at a suggestive significance level (P < 1 × 10⁻⁴), as identified by exome-wide screening

rs ID	Chr.	Position	Nearest gene	SNP type	Variant allele	MAF	β^a	SE	P-value
rs11066280	12	111302166	C12orf51	intronic	A	0.170	−0.331	0.070	2.88 × 10⁻⁶
rs2074356	12	111129784	C12orf51	intronic	A	0.140	−0.348	0.074	2.98 × 10⁻⁶
rs11066015	12	110652392	ACAD10	intronic	A	0.156	−0.329	0.071	3.97 × 10⁻⁶
rs671	12	110726149	ALDH2	nonsynonymous	A	0.155	−0.328	0.071	4.40 × 10⁻⁶
rs3782886	12	110594872	BRAP	synonymous	G	0.165	−0.319	0.070	6.27 × 10⁻⁶
rs12229654	12	109898844	MYL2	intergenic	C	0.139	−0.331	0.075	1.28 × 10⁻⁵
rs2228539	19	6877378	EMR1	nonsynonymous/splicing	G	0.015	0.903	0.215	3.18 × 10⁻⁵
rs2745099	16	1477459	PTX4	nonsynonymous	A	0.095	−0.354	0.086	4.80 × 10⁻⁵
rs41268474	1	150959136	C1orf68	nonsynonymous	A	0.058	0.441	0.111	7.90 × 10⁻⁵
rs2667672	16	1476381	PTX4	nonsynonymous	A	0.118	−0.317	0.080	8.76 × 10⁻⁵
rs2745097	16	1476500	PTX4	nonsynonymous	A	0.118	−0.317	0.080	8.76 × 10⁻⁵
rs6126559	20	35990690	VSTM2L	intronic	A	0.401	0.217	0.055	9.50 × 10⁻⁵

Chr chromosome, MAF minor allele frequency, SE standard error
^abeta coefficient was adjusted for age, sex and smoking status by multiple linear regression analysis with an additive genetic model

ISSN: 1476-069X